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Skip to Search Results- 2Srivastava, Nutan
- 1Fei Wang
- 1Gushue, Danielle L
- 1Malik, Manoj K
- 1Moussa, Eman W
- 1Stanislaus, Avalyn E
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Fall 2016
Antemortem identification of Creutzfeldt-Jakob disease (CJD) patients is initially based upon clinical presentation of the disease. Symptoms are assessed in combination with results from cerebrospinal fluid (CSF) analysis, electroencephalography (EEG), magnetic resonance imaging (MRI), and...
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Fall 2019
This thesis focuses on the development and application of electrospray ionization mass spectrometry (ESI-MS) based methods for characterizing glycoproteins (GPs) and investigating their interactions with glycan binding proteins (GBPs) and drugs. A multipronged approach was developed to identify...
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Spring 2020
In the field of metabolomics, mass spectrometry (MS) is the most widely adopted method for identifying metabolites. Conventionally, metabolite identification involves matching the target mass spectrum against experimentally acquired reference mass spectral libraries. However, the limited coverage...
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Lipidomics of Biological Samples for the Assessment of Physiological and Pathological Processes
DownloadFall 2020
Lipids are a large class of hydrophobic molecules involved in energy storage, signaling, modulation of gene expression and membranes. Lipidomics focuses on the comprehensive analysis of lipids and their interactions. Although the potential of lipidomics to study physiological and pathological...
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Measuring proteomic changes associated with viral infections and neurodegenerative diseases using mass spectrometry
DownloadFall 2023
Viral infection and the resultant cellular stress can trigger significant changes to the cellular host proteome. Viral proteases essential to viral replication have been shown to cleave human host protein substrates as a mechanism of immune response evasion. The severe acute respiratory syndrome...
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Metabolite Identification and Quantification in Biofluids Using Liquid Chromatography Mass Spectrometry
DownloadFall 2012
Metabolomics, one of the branches of systems biology, is the comprehensive measurement of all the endogenous metabolites in a biological system. It can be applied in the areas of biomarker discovery and diagnosis of critical diseases and disorders, and can significantly increase our understanding...
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Spring 2015
Neutrophils are highly abundant innate immune cells that are important in immediate responses to injury and infection, and secrete the proinflammatory cytokine tumor necrosis factor (TNF). Inflammatory cytokines have many potent effects and their excess or deficiency may have many clinical...
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Spring 2015
Neutrophils are highly abundant innate immune cells that are important in immediate responses to injury and infection, and secrete the proinflammatory cytokine tumor necrosis factor (TNF). Inflammatory cytokines have many potent effects and their excess or deficiency may have many clinical...
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Putative ante-mortem indicators of Alzheimer’s dementia: Analysis of fluid biomarker and neuroimaging studies
DownloadSpring 2019
Dementia is a clinical state, characterized by symptoms indicative of deterioration of memoryand cognitive functions that interferes with social or occupational functioning. According to2018 statistics, around 50 million people are living with dementia, and this number will increaseto 131.5...