Search
Skip to Search Results- 1Armanious, Gareth
- 1Bak, Jessi J.
- 1Chisholm, Roderick A.
- 1Glaves, John Paul J
- 1Gorski, Przemyslaw A
- 1Gutiérrez, Tomás
-
Conductive Atomic Force Microscopy Study of Electron Transport Through Diazonium Derived Films and Mixed – Mode Bonded Layers on Gold and Carbon Surfaces
DownloadSpring 2012
For Molecular Electronics to become a viable replacement or complitment to current elec- tronic devices a fundamental understanding of device operation and functionality is needed. This work explores electron transport through diazonium derived molecular junctions via conductive atomic force...
-
Cryo-electron microscopy of SERCA interacting with oligomeric phospholamban and oligomeric sarcolipin
DownloadFall 2011
In 2007, heart disease was the second leading cause of death in Canadians. In heart muscle cells, calcium (Ca2+) is released from the sarcoplasmic reticulum (SR) during contraction and must be replenished for relaxation to occur. Three proteins restore Ca2+ to the SR following contraction: the...
-
Development of High Efficiency and New Selectivity Liquid Chromatographic Phases for the Separation of Ionic and Hydrophilic Analytes
DownloadFall 2013
Separation of low molecular weight ions and hydrophilic analytes is achieved by high performance ion chromatography (IC) and hydrophilic interaction liquid chromatography (HILIC). The goal of this thesis was three-fold: to increase the efficiency of IC separations by employing small particles; to...
-
Spring 2013
Electrografting permits bonding of an organic film to a conductive substrate. It is therefore important to control the formation of organic films as best as possible and to understand the linkage between the organic film and the substrate as best as possible. This work explores electrografting of...
-
Fall 2020
Eukaryotic cells are characterized by the presence of membrane-bound organelles. Close proximity between organelles has been observed for decades, but only recently we have really started to understand the importance of these contacts for cellular function. These contacts consist of areas of...
-
Exploring Atomic Force Microscopy To Probe Charge Transport Through Molecular Films And For The Development Of Combinatorial Force Microscopy
DownloadFall 2012
Since the invention of the atomic force microscope (AFM), this technology has had profound implications in the study of material science and molecular biology. The ability to visualize and perform quantitative analysis of the nanoscale properties of surfaces has provided great insights into...
-
Spring 2020
Calcium homeostasis is essential and central to a variety of cellular processes from cell life and death pathways to metabolism to muscle contraction. One component that is essential to intracellular calcium regulation is known as the sarco(endo)plasmic reticulum Ca-ATPase, or SERCA. SERCA...
-
Fall 2013
In human cells, oscillations in calcium concentration serve as a mechanism for controlling a variety of physiological processes including muscle contraction and relaxation. The sarcoplasmic reticulum (SR) is a calcium storage organelle in muscle cells that contains a calcium pump (SERCA) required...
-
Fall 2023
When calcium enters the cytosol of a muscle cell from the SR, it initiates muscle contraction, while its removal by the sarco(endo)plasmic reticulum calcium ATPase (SERCA) induces muscle relaxation. SERCA's activity is regulated by Phospholamban (PLN), which can reversibly inhibit its apparent...
-
Spring 2020
Oscillating cytosolic calcium concentrations dictate the contraction-relaxation cycles of muscle cells. Calcium release from the sarcoplasmic reticulum (SR) to the cytosol stimulates muscle contraction, while active transport of calcium back into the SR triggers muscle relaxation. Calcium...