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Skip to Search Results- 2Berry, Tanya R
- 2Farhangfar, Arazm
- 2Gänzle, Michael G.
- 2Sawyer, Michael B.
- 2Veldhoen, Richard
- 1Abbasi Dezfouli, Meysam
- 43Graduate and Postdoctoral Studies (GPS), Faculty of
- 43Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 3Kinesiology, Sport, and Recreation, Faculty of
- 2Agricultural, Food and Nutritional Science, Department of
- 2Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 2Kinesiology, Sport, and Recreation, Faculty of/Research Data and Materials (Kinesiology, Sport, and Recreation)
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Fall 2023
Angiogenesis, the process of forming new blood vessels from a pre-exciting vasculature, is an essential component of embryonic development, tissue remodelling, wound healing, and tumor growth. This process is strictly regulated by a vast array of cellular signalling pathways involving kinases,...
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Spring 2021
Vaccinia virus (VACV) has shown promise as an oncolytic agent for treating a variety of tumour types, with preliminary results suggesting that this strategy holds promise for treating breast cancer. Our lab has previously modified VACV by deleting virally-encoded enzymes responsible for dNTP...
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Increased estrogen receptor expression leads to a novel DNA binding signature which differentiates luminal A and luminal B breast cancers
DownloadFall 2018
Eighty percent of all breast cancers are estrogen receptor positive (ER+) and molecular profiling has identified two ER+ subtypes: luminal A and luminal B. The accurate diagnosis of these luminal subtypes is one of the greatest clinical challenges with current gene assays obtaining only 75%...
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Insights into the Transcriptional Regulation and Physiological Importance of Phosphatidylethanolamine N-Methyltransferase
DownloadSpring 2010
Phosphatidylcholine (PC) is made in all nucleated mammalian cells via the CDP-choline pathway. Another major pathway for PC biosynthesis in liver is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). We have identified 3T3-L1 adipocytes as a cell culture model that expresses PEMT...
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Fall 2020
The mammalian transient receptor potential (TRP) channels, composed of six subfamilies and 28 members, play crucial roles in sensory physiology and malfunctions of TRP channels cause channelopathies. High-resolution structures of TRP channels indicate conformational arrangements showing physical...
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Investigation of BCL-2 interacting killer (BIK) as a breast cancer biomarker and its role in failed apoptosis
DownloadSpring 2019
Breast cancer is the number one cause of cancer-associated deaths in women worldwide. It can be broadly classified into estrogen receptor (ER) positive or -negative subtypes which form the basis of treatment. Despite the therapeutic advancements, more than half a million women annually succumb to...
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Investigation of the BRCT repeats in human hereditary breast cancer and DNA damage response
DownloadFall 2009
The C-terminal region of breast cancer susceptibility gene 1 (BRCA1) contains a pair of tandem BRCT repeats that are critical for the tumour suppressor function of BRCA1. BRCT repeats are present in a large of number of proteins that are implicated in the cellular response to DNA damage. A subset...
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2012
Ketabi, Ali, Baracos, Vickie E., Field, Catherine J., Lin, Xiaoxi, Xue, Hongyu, Bibova, Ilona, Gänzle, Michael G., Dieleman, Levinus A., Sawyer, Michael B.
Intestinal microbiota mediate toxicity of irinotecan (CPT-11) cancer therapies and cause systemic infection after CPT-11-induced loss of barrier function. The intestinal microbiota and their functions are thus potential targets for treatment to mitigate CPT-11 toxicity. However, microbiota...
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Lipid Modified Polymers for Transfection of Human CRL Fibroblasts, and for siRNA Mediated MDR Reversal in Melanoma Cancer Therapy
DownloadFall 2010
Gene delivery for therapeutic purposes is quickly emerging as the best potential treatment option for inherited genetic diseases and cancer. Viral gene carriers have been the choice for this purpose due to their high efficiency, but harmful immunogenic and oncogenic host reactions have limited...
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Living at-Risk for Hereditary Breast Cancer: The Experiences of at-Risk Unaffected Women Who Live in Families Where a BRCA Gene Mutation Could Not be Found
DownloadSpring 2016
Harmful mutations in the breast cancer 1 and 2 genes (BRCA1/2) and other breast cancer susceptibility genes are thought to account for less than 30% of familial breast cancer cases. Many affected women (those with a personal history of breast and/or ovarian cancer) who undergo BRCA1/2 genetic...