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Evaluating the Role of Bacterial Lipopolysaccharide on Etiology and Pathogenesis of Transmissible Spongiform Encephalopathies
DownloadFall 2014
Transmissible spongiform encephalopathies (TSEs) or otherwise known as prion diseases are a class of fatal neurodegenerative diseases related to irreversible brain damage. Presently, there is no effective treatment or preventive strategy for this disease because the etiology and biological...
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Hippocampal neuroplasticity and neurogenesis in major depressive disorder: a high field MRI study
DownloadFall 2012
The hippocampus is a brain structure responsible for memory, learning, and the stress response; it is also used as a model for major depressive disorder (MDD) in preclinical studies. Preclinical models have shown that the hippocampal subfields are differentially affected by chronic stress....
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Investigating the Behavioral and Neural Impact of Skill and Goal-based Interventions in Adults with Dyslexia
DownloadSpring 2023
Developmental dyslexia is a neurodevelopmental disorder that is characterized by persistent reading and spelling difficulties despite adequate intelligence and educational opportunities. In addition to literacy-based difficulties, individuals with dyslexia also have difficulties with their...
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Spring 2016
Image segmentation is the problem of assigning 2D pixels or 3D voxels to a set of finite labels. In particular, in medical imaging, the goal of segmentation is to partition an MRI or CT image into regions that are relevant to the biology of a particular disease, for example the motor cortex in...
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Fall 2016
Understanding human immunodeficiency-1 (HIV-1) replication and latency in different reservoirs is an ongoing challenge in the care of patients with HIV/AIDS. A mathematical model was created that predicted HIV-1 and simian immunodeficiency virus (SIV) infection dynamics within the brain during...
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Optical Measurement of Directional, Regional, and Strain Rate Dependent Mechanical Properties of Human Brain Tissue under Uniaxial Compression
DownloadSpring 2024
The brain is the most important central nervous system component, consisting of a complex network of neurons and glial cells essential for information processing, movement, and behavior control. While computational models have helped advance the development of diagnostic tools and the...
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Reservoir and geomechanical coupled simulation of CO2 sequestration and enhanced coalbed methane recovery
DownloadFall 2009
Coalbeds are an extremely complicated porous medium with characteristics of heterogeneity, dual porosity and stress sensitivity. In the past decades great achievements have been made to the simulation models of pressure depletion coalbed methane (CBM) recovery process and CO2 sequestration and...