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Skip to Search Results- 1Alsaikhan, Bader H
- 1Araya, Luam Ellen
- 1Baghdasarian, Argishti
- 1Brennan, Lesley Jean
- 1Chan, Calvin J
- 1Chaurasiya, Shyambabu
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Fall 2023
Polysialic acid (polySia) is a long homopolymer of sialic acid residues that has profound consequences for the proteins it is attached to. Its expression is restricted in healthy human adults to the nervous, reproductive, and immune systems. It contributes to neuronal development and plasticity...
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A proteome-level analysis of the canola/Sclerotinia sclerotiorum interaction and sclerotial development
DownloadFall 2010
The fungal pathogen Sclerotinia sclerotiorum (Lib.) de Bary is capable of infecting over 400 plant species including canola (Brassica napus L.). The fungus secretes oxalic acid (OA), which plays an important role in infection and disease progression. An analysis of proteome-level changes...
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Spring 2016
The simultaneous quantification of all biological molecules, from metabolites to proteins, holds the key to discovering molecular signatures that can diagnose diseases before irreversible damages have occurred in the body. Recent advances in the field of liquid chromatography coupled mass...
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An investigation of aminoglutethimide cytotoxicity and its role in activation of cell death signaling pathways
DownloadFall 2013
Aminoglutethimide (AG), a drug used for the treatment of breast and ovarian cancers, is known to cause toxicities such as agranulocytosis. To investigate its toxicity mechanisms, we have used quantitative proteomic analysis to gain insight into the proteome of Human Leukemia 60 (HL-60) treated...
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Fall 2016
Antemortem identification of Creutzfeldt-Jakob disease (CJD) patients is initially based upon clinical presentation of the disease. Symptoms are assessed in combination with results from cerebrospinal fluid (CSF) analysis, electroencephalography (EEG), magnetic resonance imaging (MRI), and...
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Fall 2015
Abstract The ability to identify and remove sub-fertile boars from the breeding herd is critical to improving reproductive efficiency of pork production systems. Use of semen from sires exhibiting sub-fertility can result in decreased sow pregnancy and farrowing rates, as well as smaller litter...
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Characterization of the Mitochondrial Phenotype Associated with Primary Biliary Cholangitis
DownloadSpring 2017
Primary Biliary Cholangitis (PBC) is a chronic liver disease characterized by the immune-mediated destruction of intra-hepatic bile ducts. The autoimmune nature of PBC involves humoral and cell-mediated responses that target endogenous mitochondrial proteins. It is thought that the breakdown of...
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Deletion of F4L (ribonucleotide reductase) in Vaccinia Virus Produces a Selective Oncolytic Virus and Promotes Anti-tumor Immunity with Superior Safety in Bladder Cancer
DownloadFall 2017
Overall recurrence of non-muscle-invasive bladder cancer (NMIBC) can be as high as 80% within 5 years of initial treatment. High-grade NMIBC has the greatest risk of recurrence and treatment for these patients includes surgery followed by intravesical therapy with the immunotherapeutic agent...
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Delivery of STAT3 inhibitor cucurbitacins to tumor by polymeric nano-carriers : Implications in cancer chemo- and immunotherapy
DownloadFall 2009
Signal Transducer and Activator of Transcription 3 (STAT3), a common oncogenic mediator, is constitutively activated in many types of human cancers and plays a critical role in tumor growth and cancer immune evasion. The focus of this dissertation is the delivery of STAT3 inhibitor cucurbitacins...
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Development and application of mass spectrometry for bioanalysis of proteins and metabolites
DownloadSpring 2011
The proteome, a hybrid term from protein and genome, is the total set of proteins expressed by a genome in a cell, tissue, or organism at a given time. Proteomics, the study of the proteome, is concerned with a variety of topics such as identity, quantity, activity, structure, protein-protein...