Search
Skip to Search Results- 8Nitric Oxide
- 6Vasoconstriction
- 4Sympatholysis
- 3Exercise
- 3Sympathetic nervous system
- 2Blood pressure
- 1Brotto,Andrew R
- 1Collison, Breanne
- 1Cooper, Ian R
- 1Cox, Pendleton J M
- 1El-Sehemy, Ahmed Ali Ahmed Ali
- 1Forbes, Scott C
- 5Physical Education and Recreation
- 2Department of Physiology
- 2Faculty of Kinesiology, Sport, and Recreation
- 1Department of Biological Sciences
- 1Department of Oncology
- 1Faculty of Pharmacy and Pharmaceutical Sciences
- 1Bell, Gordon (Physical Education and Recreation)
- 1Carlos A Velázquez (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Darren DeLorey, PhD Faculty of Physical Education and Recreation; Rehabilitation Medicine
- 1Davidge, Sandra (dept. of Physiology)
- 1DeLorey, Darren (Physical Education and Recreation)
- 1DeLorey, Darren Faculty of Kinesiology, Sport, and Recreation
-
Anesthesia and the Aging Vasculature: Effects of Propofol on Hemodynamics and Vascular Function
DownloadSpring 2014
An increasing life expectancy in Canada has resulted in increasing proportions of elderly patients requiring anesthetic care for surgical procedures. Aging is associated with cardiovascular changes resulting in increased vasoconstriction and hypertension, and medications such as angiotensin...
-
Are Sex and Estrogen Modulators of Sympathetic Vascular Control in Resting and Contracting Skeletal Muscle?
DownloadSpring 2018
The purpose of this thesis was to investigate whether sex and estrogen modulate sympathetic neurovascular control in resting and contracting skeletal muscle. This thesis also investigated the hypothesis that the effects of sex and estrogen on neurovascular control would be mediated by the signal...
-
Can L-arginine Influence the Acute Hormonal, Metabolic, and Physiological Responses at Rest and Prior to Exercise?
DownloadFall 2012
L-arginine is a conditionally essential amino acid and has recently been purported as ergogenic for both strength and aerobic athletes; however, the value of oral L-arginine supplementation in physically active participants is controversial. The purpose of this dissertation was threefold: first...
-
Spring 2012
Human cytomegalovirus (HCMV) is implicated in several vascular diseases through endothelial dysfunction. Most of the research on CMV has focused on either congenital CMV infections or CMV disease in immunocompromised hosts; however, CMV has also been associated with vascular diseases in...
-
Effect of dietary nitrate on sympathetic vasoconstriction in resting and contracting skeletal muscle
DownloadFall 2015
Dietary nitrate (NO3-) may increase nitric oxide (NO) bioavailability and alter the control of blood flow at rest and during exercise. This thesis investigated the effect of dietary NO3- supplementation on sympathetic mediated control of skeletal muscle blood flow in resting and contracting...
-
Fall 2022
Contraction-mediated inhibition of sympathetic vasoconstriction (sympatholysis) is enhanced in female compared with male rats. Acute pharmacological blockade of nitric oxide (NO) production abolished the sex difference in sympatholysis, indicating that NO-mediated sympatholysis is elevated in...
-
Spring 2017
Pulses of ecdysone, a steroid hormone, play an integral role during insect development however, how these ecdysone pulses are regulated has been relatively unexplored. I have shown that the presence of nitric oxide (NO) within the larval prothoracic gland (PG), the principal source of larval...
-
Notch regulates the growth-promoting nitric oxide cGMP-dependent pathway in epithelial ovarian cancer and ovarian surface epithelium cells
DownloadSpring 2014
El-Sehemy, Ahmed Ali Ahmed Ali
Ovarian cancer is the leading cause of mortality among gynecologic cancers. There are several subtypes of ovarian cancer, amongst which epithelial ovarian cancer (EOC) makes up to 90% of all ovarian cancers. The current treatment for EOC consists of debulking surgery followed by a...
-
NSAID Prodrugs with Improved Anti-inflammatory Activity and Low Ulcerogenicity: Wake Up Call to Pharmaceutical Companies and Health Authorities
DownloadSpring 2012
The objective of this work was to synthesize and evaluate the biological properties of a new series of nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs) possessing a tyrosol linker between the carboxylic acid present in classical NSAIDs and a NO-releasing group (PROLI/NO)...
-
Skeletal Muscle Sympathetic Vasoconstrictor Control Following Short-Term Mild- and Heavy-Intensity Exercise Training
DownloadFall 2013
The purpose of this thesis was to investigate the effects of short-term endurance exercise training (ET) on sympathetic vasoconstriction in resting and contracting skeletal muscle. To achieve these aims, rats were exercise trained on a motorized treadmill and an anesthetised whole animal in situ...