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- 15Randomized Controlled Trials as Topic
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- 19Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
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An Analysis of the Environmental Risk Factors of Childhood Asthma and Asthma-like Symptoms: Results from the National Longitudinal Survey of Children and Youth
DownloadSpring 2016
It is known that a multitude of environmental factors are implicated in the incidence of asthma and asthma symptoms among children; however, previous research has provided inconsistent and/or insufficient evidence as to whether residing in a farming environment during childhood can lead to a...
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An Exploration of the Associations Between Gut and Serum Immunoglobulin A in Infancy and Asthma in Childhood
DownloadSpring 2020
Introduction Early immune maturation and gut microbial composition have a clear impact on the development of asthma and atopy in children. There is a large body of evidence on the association between immunoglobulin A (IgA), asthma, and other atopic diseases. Low secretory Immunoglobulin A (sIgA)...
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Applying the risk of bias tool in a systematic review of combination long-acting beta-agonists and inhaled corticosteroids for persistent asthma.
Download2011
Seida, J., Vandermeer, B., Hartling, L., Dryden, D. M., Rowe, B. H., Bond, K.
Background The Risk of Bias (RoB) tool is used to assess internal validity of randomized controlled trials (RCTs). Our objectives were to: 1) evaluate inter-rater agreement of the RoB tool; 2) determine the time to access supplemental study information; 3) compare the RoB tool with the Jadad...
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Spring 2014
Inconsistent results have been reported in studies investigating the relationship between serum vitamin D levels and respiratory outcomes. In this thesis, data from the Canadian Health Measures Survey were used to examine the relationship between serum 25-hydroxy vitamin D [25(OH)D] levels and...
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Spring 2018
Introduction: Asthma is a chronic inflammatory disease characterized by intermittent episodes of acute airway inflammation and bronchoconstriction. Although asthma is generally considered a disease of the airways, asthma is also associated with an increased risk of developing cardiovascular (CV)...
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Children are not just small adults: the urgent need for high-quality trial evidence in children.
Download2008
Offringa, M., Hartling, L., Craig, J. C., Klassen, T. P.
Children are often touted as being very important members of society because they represent our future. Optimizing their health outcomes has the potential for a huge impact on public health because children are at an early stage in the life trajectory. But it is often unclear how society...
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2005
Swingler, G., Williams, K., Hartling, L., Moyer, V., Cramer, K., Klassen, T. P., Wiebe, N.
Background The delivery of optimal medical care to children is dependent on the availability of child relevant research. Our objectives were to: i) systematically review and describe how children are handled in reviews of drug interventions published in the Cochrane Database of Systematic Reviews...