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Association between Asthma and Vitamin D in Children, Adolescents and Adults

  • Author / Creator
    John Niruban, Selvanayagam
  • Inconsistent results have been reported in studies investigating the relationship between serum vitamin D levels and respiratory outcomes. In this thesis, data from the Canadian Health Measures Survey were used to examine the relationship between serum 25-hydroxy vitamin D [25(OH)D] levels and respiratory outcomes. Children with 25(OH)D levels less than 50 nmol/L and greater than 75 nmol/L had increased risk of current wheeze and reduced cross- sectional changes in lung function with age in comparison to those children with 25(OH)D levels between 50 and 74nmol/L suggesting a U-shaped relationship between 25(OH)D levels and these respiratory outcomes in children. The lower 25(OH)D category was also a significant risk factor for asthma attacks in adolescents and adults. Monitoring of serum vitamin D level may enhance management of respiratory conditions in children, adolescents and adults. Further exploration of this relationship is needed to identify the optimal level of vitamin D for respiratory outcomes.

  • Subjects / Keywords
  • Graduation date
    2014-06
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R3JT37
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Department of Public Health Sciences
  • Specialization
    • Clinical epidemiology
  • Supervisor / co-supervisor and their department(s)
    • Senthilselvan, Ambikaipakan (Department of Public Health Sciences)
    • Alagiadrishnan, Kannayiram (Department of Medicine)
    • Beach, Jeremy (Department of Medicine)
  • Examining committee members and their departments
    • Veugelers, Paul (Department of Public Health Sciences)