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Skip to Search Results- 2Veldhoen, Richard
- 1Abdelrahman, Ali Satti Abdellatif
- 1Abdualmjid,Reem J
- 1Abdurrahim, Amna E.
- 1Allen, D. M.
- 1Allison, W. T.
- 55Graduate and Postdoctoral Studies (GPS), Faculty of
- 55Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 3WISEST Summer Research Program
- 3WISEST Summer Research Program/WISEST Research Posters
- 2Biological Sciences, Department of
- 2Biological Sciences, Department of/Journal Articles (Biological Sciences)
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Spring 2012
In Pulmonary Arterial Hypertension (PAH), pro-constrictive, pro-proliferative and anti-apoptotic diatheses converge to produce contraction and excessive proliferation of pulmonary artery smooth muscle cells (PASMC), a hallmark of PAH-vascular remodeling. The increased afterload causes right...
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An investigation of aminoglutethimide cytotoxicity and its role in activation of cell death signaling pathways
DownloadFall 2013
Aminoglutethimide (AG), a drug used for the treatment of breast and ovarian cancers, is known to cause toxicities such as agranulocytosis. To investigate its toxicity mechanisms, we have used quantitative proteomic analysis to gain insight into the proteome of Human Leukemia 60 (HL-60) treated...
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Analysis of goldfish innate immunity following exposure to oil sands process affected water
DownloadFall 2013
The acute and sub chronic effects of oil sands process affected water (OSPW) and its toxic component, naphthenic acids (NAs) were examined. I exposed goldfish for one (acute), or 12 (sub chronic) weeks and examined immune gene expression, macrophage function, the ability of exposed fish to...
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Anthocyanins and Gingerols Exhibit Synergism in their Anticancer and Antioxidant Effects in Vitro
DownloadFall 2022
Anthocyanins and gingerols are naturally occurring phenolic compounds abundant in berries and ginger, respectively. They have been reported to induce antioxidant effects, inhibit the growth of different cancer cell lines, and stimulate apoptosis by modulating different cellular signal pathways....
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Application of coagulation-flocculation process for treating oil sands process-affected water
DownloadFall 2011
Oil Sands Process-Affected Water (OSPW) is generated from oil sands operation processes such as mining, extraction, and upgrading. Currently, accumulated OSPW is temporarily stored in tailings ponds which are toxic to the environment and must be treated for either reuse or safe discharge in the...
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Fall 2012
Taxane chemotherapy is widely used in the treatment of breast cancer. Despite its widespread clinical use, the molecular mechanisms of paclitaxel induced apoptosis remain unclear. Our laboratory has identified an important role for the BH3-only protein, BAD, in the paclitaxel induced cell death...
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Biological Treatment of Naphthenic Acids and Other Organic Compounds in Oil Sands Process-Affected Waters
DownloadFall 2014
The Alberta oil sands contain one of the world’s largest reserves of oil - over 169 billion barrels of bitumen are economically recoverable with current extraction technologies. Surface mining, whereby the ore is extricated from the earth and bitumen is obtained via a hot water extraction...
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Fall 2019
The extraction, transport and refining of crude oil generates a diverse group of contaminants that pose a risk to both fresh and saltwater fishes. Adult fish can detect and actively avoid exposure to these pollutants; however, the embryonic and larval fish cannot outswim a toxic plume and are...
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Spring 2014
The introduction of WNV into North America in 1999 was followed by rapid spread throughout the continent. Today, WNV is an endemic pathogen in the west, with thousands of cases of severe infection reported annually. In addition to traditional vaccine research, there is an urgent need to...