Search
Skip to Search Results- 1Anderson-Baron, Matthew N
- 1Chang, Jinlan
- 1Herman, Emily K
- 1Hou, Shangmei
- 1Klute, Mary J.
- 1Lambkin, Gareth Robert.
-
A comprehensive assessment of peroxisome biology: ER-dependent peroxisome proliferation control, evolution of organelle inheritance in yeast and a Drosophila model system of Zellweger syndrome
DownloadFall 2013
The modern eukaryotic cell is a meshwork of encapsulating membranes that compartmentalize many distinct biochemical processes. It is complex. This complexity facilitates the many unique and diverse processes that aid the eukaryote in its growth, division and adaptation to its environment. A...
-
An ancestral role in de novo peroxisome assembly is retained by the divisional peroxin Pex11 in the yeast Yarrowia lipolytica
DownloadFall 2014
This thesis is on peroxisome evolution and reports my findings with regard to two major aspects of this process. First, I investigated the evolution of a peroxisomal protein family for which large expansions had been noted in diverse eukaryotes from a comparative genomic perspective and combined...
-
Fall 2017
Flaviviruses are important human pathogens that have an enormous impact on global health. Examples that have been studied in my research include dengue virus (DENV), West Nile virus (WNV) and most recently, Zika virus (ZIKV). Currently, there are very few vaccines against or therapeutic...
-
Spring 2016
Schlacht, Alexander Douglas William
One of the features that distinguishes eukaryotes from prokaryotes is the membrane trafficking system. This system underpins much of the functionality of the eukaryotic cell, and is necessary for feeding, motility and communication. Analyses aimed at addressing the evolution of this system have...
-
Hsp90 and its co-chaperones regulate the activity of human Argonaute2 in RNA-mediated silencing pathways
DownloadFall 2011
The potent ability of small, double-stranded RNAs to silence gene expression was initially reported 1998, sparking revolutions in molecular biology and genetics. Since then, intensive research into the mechanism of RNA-mediated silencing has implicated the machinery of this pathway in the...
-
Fall 2010
Peroxisomes are indispensable organelles that perform many essential metabolic activities. Thus, eukaryotic cells have evolved molecular mechanisms to ensure the inheritance of peroxisomes from mother cell to daughter cell at cell division. In the budding yeast Saccharomyces cerevisiae, the class...
-
Spring 2019
Organelles serve to compartmentalize biochemical functions within the eukaryotic cell. However, to collectively maintain cellular homeostasis, organelles must communicate in some way in order to coordinate these functions. Two such organelles,the peroxisome and the lipid droplet, are both...
-
Fall 2013
Ortiz Sandoval, Carolina Guadalupe
The ER mitochondria-associated membrane (MAM) is a hub for many calcium-mediated processes required for cell survival, including apoptosis, autophagy, and ATP production. In this thesis, we identified and characterized the interaction between MAM-enriched Rab32 and its effector Drp1, a master...
-
Understanding the evolution of the membrane trafficking system in diverse eukaryotes through comparative genomics and transcriptomics
DownloadSpring 2018
Single-celled organisms represent the majority of eukaryotic diversity. Recent advances in sequencing technologies have been critical for understanding the evolutionary biology and cell biology of microbial eukaryotes. Comparative genomic analyses have shown that many genes that underlie...