This decommissioned ERA site remains active temporarily to support our final migration steps to https://ualberta.scholaris.ca, ERA's new home. All new collections and items, including Spring 2025 theses, are at that site. For assistance, please contact erahelp@ualberta.ca.
Search
Skip to Search Results- 2Aguzzi, Adriano
- 2Ametaj, Burim N.
- 2Dunn, Suzanna M.
- 2James, Michael N. G.
- 1Baral, Pravas K.
- 1Bellon, Anne
-
Crystallization and preliminary X-ray diffraction analysis of prion protein bound to the Fab fragment of the POM1 antibody
Download2011
James, Michael N. G., Swayampakula, Mridula , Polymenidou, Magdalini , Kav, Nat N. V., Aguzzi, Adriano, Wieland, Barbara, Baral, Pravas K.
Prion diseases are neurodegenerative diseases that are characterized by the conversion of the cellular prion protein PrPc to the pathogenic isoform PrPsc. Several antibodies are known to interact with the cellular prion protein and to inhibit this transition. An antibody Fab fragment, Fab POM1,...
-
Intravaginal lactic acid bacteria modulated local and systemic immune responses and lowered the incidence of uterine infections in periparturient dairy cows
Download2015
Dunn, Suzanna M., Odhiambo, John F., Farooq, Umar, Ametaj, Burim N., Lam, Tran, Deng, Qilan
The objective of this investigation was to evaluate whether intravaginal infusion of a lactic acid bacteria (LAB) cocktail around parturition could influence the immune response, incidence rate of uterine infections, and the overall health status of periparturient dairy cows. One hundred pregnant...
-
Repeated oronasal exposure to lipopolysaccharide induced mucosal IgA responses in periparturient dairy cows
Download2014
Dunn, Suzanna M., Iqbal, Summera, Zebeli, Qendrim, Mansmann, Dominik A., Ametaj, Burim N.
This study investigated the effects of repeated oronasal treatment with lipopolysaccharide (LPS) on the humoral immune responses in saliva, vaginal mucus, and the plasma markers of the acute phase response in periparturient dairy cows. One hundred pregnant Holstein cows were administered either 3...
-
Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile
Download2014
Ng, Kenneth K. S., Tanha, Jamshid, Kitova, Elena N., Eugenio, Luiz, Murase, Tomohiko, Klassen, John S., Hussack, Greg, Schorr, Melissa
Clostridium difficile infection is a serious and highly prevalent nosocomial disease in which the two large, Rho-glucosylating toxins TcdA and TcdB are the main virulence factors. We report for the first time crystal structures revealing how neutralizing and non-neutralizing single-domain...
-
The POM monoclonals: A comprehensive set of antibodies to non-overlapping prion protein epitopes
Download2008
Hafner-Bratkovič, Iva, Aguzzi, Adriano, Vey, Martin, Polymenidou, Magdalini, Yajima, Bill , James, Michael N. G., Jerala, Roman, Moos, Rita, Scott, Mike, Shi, Yong-zhong, Wuthrich, Kurt, Garen, Graciela, Sigurdson, Christina, Hornemann, Simone, Bellon, Anne, Kav, Nat
PrPSc, a misfolded and aggregated form of the cellular prion protein PrPC, is the only defined constituent of the transmissible agent causing prion diseases. Expression of PrPC in the host organism is necessary for prion replication and for prion neurotoxicity. Understanding prion diseases...