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Skip to Search Results- 2Aguzzi, Adriano
- 2Baral, Pravas K.
- 2James, Michael N. G.
- 2Kav, Nat N. V.
- 2Polymenidou, Magdalini
- 2Swayampakula, Mridula
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Crystallization and preliminary X-ray diffraction analysis of prion protein bound to the Fab fragment of the POM1 antibody
Download2011
James, Michael N. G., Swayampakula, Mridula , Polymenidou, Magdalini , Kav, Nat N. V., Aguzzi, Adriano, Wieland, Barbara, Baral, Pravas K.
Prion diseases are neurodegenerative diseases that are characterized by the conversion of the cellular prion protein PrPc to the pathogenic isoform PrPsc. Several antibodies are known to interact with the cellular prion protein and to inhibit this transition. An antibody Fab fragment, Fab POM1,...
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Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1
Download2012
Kav, Nat N. V., Polymenidou, Magdalini , Rahman, Muhammad H., Aguzzi, Adriano, Swayampakula, Mridula , James, Michael N. G., Baral, Pravas K., Wieland, Barbara
Prion diseases are neurodegenerative diseases characterized by the conversion of the cellular prion protein PrPc into a pathogenic isoform PrPsc. Passive immunization with antiprion monoclonal antibodies can arrest the progression of prion diseases. Here, the crystal structure of the Fab fragment...