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Skip to Search Results- 2Fliegel, Larry
- 2Michalak, M.
- 1Abdul Rahman, Siti Aishah
- 1Alles, Sascha R
- 1Arantes, A. S.
- 1Asher, B.J.
- 35Graduate and Postdoctoral Studies (GPS), Faculty of
- 35Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 4Agricultural, Food and Nutritional Science, Department of
- 4Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 4Biological Sciences, Department of
- 4Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 5Centre for Neuroscience
- 5Department of Biological Sciences
- 4Department of Agricultural, Food, and Nutritional Science
- 3Department of Pharmacology
- 3Department of Physiology
- 3Neuroscience
- 2Tse, Amy (Centre for Neuroscience and Department of Pharmacology)
- 1Ballanyi, Klaus (Physiology Department, University of Alberta)
- 1Basarab, John (Alberta Agriculture and Rural Development)
- 1Chen, Xing-Zhen (Physiology)
- 1Clayton T. Dickson (Psychology, Physiology, Anesthesia and Pain Medicine, Neuroscience and Mental Health Institute)
- 1Colmers, William F. (Pharmacology)
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Electrophysiological and Genetic Aspects of Age-Related Macular Degeneration (AMD): Treatment Implications
DownloadFall 2014
Age-related macular degeneration (AMD) is considered a heterogeneous group of disorders. Although many genes influence susceptibility to disease, none has shown to be the primary contributor. To identify genetic contributors, distinct AMD phenotypes need to be established. We relied on...
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Spring 2012
Neuropathic pain afflicts 1.5-3% of the general population. It can be initiated by traumatic nerve injuries or diseases such as diabetic or post-herpetic neuropathy. Neuropathic pain is often initiated by abnormal spontaneous activity in sensory neurons and this provokes increased excitability of...
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Emerging pathways in the regulation of whole body cholesterol flux: Therapeutic opportunities to target atherosclerosis?
Download2014
Mangat, Rabban, Proctor, Spencer D.
INTRODUCTION: CVD remains one of the most frequent causes of morbidity and mortality globally. Increased awareness of lifestyle factors (nutrition/exercise), as well as the refinement of lipid-lowering therapies, has availed some progress in reducing the incidence of CVD. Historically, the...
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2006
Wilson, A.J., Pemberton, J.M., Coltman, D.W., Kruuk, L.E.B., Pilkington, J.G., Mifsud, D.V., Clutton-Brock, T.H.
There has recently been great interest in applying theoretical quantitative genetic models to empirical studies of evolution in wild populations. However, while classical models assume environmental constancy, most natural populations exist in variable environments. Here, we applied a novel...
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Expansion of ruminant-specific microRNAs shapes target gene expression divergence between ruminant and non-ruminant species
Download2013
Kommadath, A., Bao, H., Meng, Y., Plastow, G. S., Stothard, P., Sun, X., Arantes, A. S., Guan, L. L.
Background Understanding how species-specific microRNAs (miRNAs) contribute to species-specific phenotypes is a central topic in biology. This study aimed to elucidate the role of ruminant-specific miRNAs in shaping mRNA expression divergence between ruminant and non-ruminant species. ...
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2014
Conroy, Sherrill A., Murray, Cynthia L.
Low maternal, gestational weight gain is associated with preterm birth, intrauterine growth restriction, low birthweight, small-for-gestational-age infants, neural tube defects, infant death, failure to initiate breastfeeding, and childhood asthma. The advantage of qualitative research is it can...
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Spring 2019
DNA-templated reactions have been utilized in many applications from the detection of a nucleic acid target to applications in nanotechnology. This thesis explores developing bioanalytical strategies based on DNA-templated ligation reactions for sensitive, rapid single nucleotide polymorphism...
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2012
Wang, Lusheng, Moore, Steve S., Cai, Zhipeng, Goebel, Randy, Lin, Guohui, Wang, Yining, Stothard, Paul
Background Single nucleotide polymorphism (SNP) genotyping assays normally give rise to certain percents of no-calls; the problem becomes severe when the target organisms, such as cattle, do not have a high resolution genomic sequence. Missing SNP genotypes, when related to target traits, would...
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Fall 2015
Polycystic kidney disease (PKD) protein 2 Like 1 (PKD2L1), also called transient receptor potential polycystin-3 (TRPP3), regulates Ca2+-dependent hedgehog signalling in primary cilia, intestinal development and sour tasting but with an unclear mechanism. PKD2L1 is a Ca2+-permeable cation channel...
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Genetic structure of a large recolonizing carnivore: the case of the northern cougars (Puma concolor)
DownloadFall 2023
Anthropogenic activities have pressured and altered landscapes resulting in extinctions and extirpations. However, increased conservation efforts and changing management strategies in some large carnivores have resulted in population and range expansion. Population growth and range expansion are...