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Challenges for Resource Allocation, Decision Making and Consideration of Social Values for Screening, Diagnosis and Treatment of Hepatitis C in Canadian Populations
DownloadFall 2018
Introduction: Health care system decision makers face challenges in allocating resources for screening, diagnosis and therapies for hepatitis C, caused by the highly infectious and blood borne hepatitis C virus (HCV) (WHO, 2014). Approximately 240,000 individuals are infected with HCV in Canada...
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Chart review of current end-of-life care needs and care practices in acute care hospitals: final report of an investigation
DownloadSpring 2011
A total of 1,018 charts of people who died from August 1, 2008 through July 31, 2009 were reviewed to describe and examine current end-of-life care needs and care practices provided in two acute care hospitals. The mean age of those who died was 72.5, the majority of decedents were elderly...
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Spring 2013
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
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Clinical Implications of Historical Development of the DSM through Examining Two Main Disorders
DownloadFall 2013
As a gateway to support for those who experience significant distress or impairment as a result of cognitive, affective, developmental, social, environmental, or other personal/interpersonal challenges, mental disorder diagnosis is a common practice in mental health professions. In order to...
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Spring 2019
The pre and post diagnostic phases of amyotrophic lateral sclerosis (ALS) care are inherently uncertain for patients and caregivers. The emotional character of ALS related communications requires that providers have a high degree of skill and tact. Understanding patient and caregiver preferences...
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Data-Driven Approaches to Modeling Heterogeneity and Variability Across Asymptomatic Brain and Cognitive Aging, Mild Cognitive Impairment, and Alzheimer’s disease
DownloadSpring 2024
Objective We apply data-driven approaches to identify predictors of heterogeneous trajectories across normal aging, Mild Cognitive Impairment (MCI), and Alzheimer’s disease (AD). In Study 1, we investigated predictors of left and right hippocampal (HC) volume trajectory classes. In Study 2, we...
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2011
Innes, Anthea, Morgan, Debra, Kosteniuk, Julie
Objectives: The purpose of this review is to critically evaluate the available evidence from the published scientific literature on dementia care and service provision in rural and remote settings from the perspective of formal/paid caregiving, in order to assess the current state of knowledge,...
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Differences in Whole Blood Gene ExpressionAssociated with Infection Time-Course andExtent of Fetal Mortality in a ReproductiveModel of Type 2 Porcine Reproductive andRespiratory Syndrome Virus (PRRSV)Infection
Download2016-04-19
Wilkinson, Jamie M., Ladinig, Andrea, Bao, Hua, Kommadath, Arun, Stothard, Paul, Lunney, Joan K., Harding, John C. S., Plastow, Graham S.
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnantfemales causes fetal death and increased piglet mortality, but there is substantial variationin the extent of reproductive pathology between individual dams. This study used RNA-sequencing to characterize the whole...
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Fall 2012
Functional Magnetic Resonance Imaging (fMRI) measures the dynamic activity of each voxel of a brain. This dissertation addresses the challenge of learning a diagnostic classifier that uses a subject’s fMRI data to distinguish subjects with neuropsychiatric disorders from healthy controls. fMRI...