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An Exploration of the Associations Between Gut and Serum Immunoglobulin A in Infancy and Asthma in Childhood
DownloadSpring 2020
Introduction Early immune maturation and gut microbial composition have a clear impact on the development of asthma and atopy in children. There is a large body of evidence on the association between immunoglobulin A (IgA), asthma, and other atopic diseases. Low secretory Immunoglobulin A (sIgA)...
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Exploring the involvement of adults with Autism Spectrum Disorder (ASD) in developing ASD research
DownloadSpring 2014
Participatory research (PR) is a research approach which involves partnerships between researchers and those affected by the issues under study. These partnerships lead to the production of research that is relevant and applicable to those involved in the process. Despite the potential value of...
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Nonmedical Use of Opioids Following Short Term Therapeutic Exposure in Children and Youth: A Systematic Review and Qualitative Study of Decision Maker Information Needs
DownloadFall 2021
Introduction Healthcare visits, hospitalizations, and deaths due to opioid-related harms continue to rise for children, despite an overall decline in opioid prescriptions. Decision-makers (including patients, families, clinicians, and policy-makers) require high quality syntheses to inform...
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Understanding the role of Clostridioides difficile and Vitamin D supplementation in shaping the gut microbiome of Canadian infants
DownloadSpring 2019
Introduction: The gut microbiome is shaped during infancy and has an important role in the development of both the immune and metabolic systems. Many early life exposures and events contribute to the composition of this complex intestinal environment, notably early infant diet and breastfeeding....