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Drosophila Mage, a component of Smc5/6 DNA response complex, confers resistance to caffeine and genotoxic stress and plays a role in the cell cycle and cell survival
DownloadFall 2014
Over 50 Melanoma-associated antigen (MAGE) genes have been identified in the human genome. They share a conserved 200 amino acid MAGE-homology domain (MHD). In yeast, the only MAGE homolog (Nse3) is a component of the Smc5/6 DNA damage response complex. In humans, MAGE proteins influence cell...
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Mathematical modelling of the effect of low-dose radiation on the G2/M transition and the survival fraction via the ATM/Chk2 pathway
DownloadSpring 2020
Radiation therapy is an important component of cancer treatment. It consists of applying ionizing radiation to kill cells by damaging their DNA and reducing their ability to reproduce and survive. It is reasonable to think that more radiation causes more damage and kills more cells. However, in...
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Fall 2021
Breast cancer is the most common cancer amongst women in Canada. The current treatment regime for early stage breast cancers is breast-conserving surgery with radiation therapy. However, 10-20% of patients develop local recurrence, and some exhibit metastatic spread, which is associated with a...