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Fall 2023

Derksen, Tahlia R L

Polysialic acid (polySia) is a long homopolymer of sialic acid residues that has profound consequences for the proteins it is attached to. Its expression is restricted in healthy human adults to the nervous, reproductive, and immune systems. It contributes to neuronal development and plasticity...

Fall 2010

Liang, Yue

The fungal pathogen Sclerotinia sclerotiorum (Lib.) de Bary is capable of infecting over 400 plant species including canola (Brassica napus L.). The fungus secretes oxalic acid (OA), which plays an important role in infection and disease progression. An analysis of proteome-level changes...

Spring 2016

Li, Zhendong

The simultaneous quantification of all biological molecules, from metabolites to proteins, holds the key to discovering molecular signatures that can diagnose diseases before irreversible damages have occurred in the body. Recent advances in the field of liquid chromatography coupled mass...

Fall 2013

Baghdasarian, Argishti

Aminoglutethimide (AG), a drug used for the treatment of breast and ovarian cancers, is known to cause toxicities such as agranulocytosis. To investigate its toxicity mechanisms, we have used quantitative proteomic analysis to gain insight into the proteome of Human Leukemia 60 (HL-60) treated...

Fall 2016

Gushue, Danielle L

Antemortem identification of Creutzfeldt-Jakob disease (CJD) patients is initially based upon clinical presentation of the disease. Symptoms are assessed in combination with results from cerebrospinal fluid (CSF) analysis, electroencephalography (EEG), magnetic resonance imaging (MRI), and...

Fall 2012

Craik, Alison C

Taxane chemotherapy is widely used in the treatment of breast cancer. Despite its widespread clinical use, the molecular mechanisms of paclitaxel induced apoptosis remain unclear. Our laboratory has identified an important role for the BH3-only protein, BAD, in the paclitaxel induced cell death...

Fall 2015

Diether, Natalie E

Abstract The ability to identify and remove sub-fertile boars from the breeding herd is critical to improving reproductive efficiency of pork production systems. Use of semen from sires exhibiting sub-fertility can result in decreased sow pregnancy and farrowing rates, as well as smaller litter...

Spring 2017

Wysokinski, Filip

Primary Biliary Cholangitis (PBC) is a chronic liver disease characterized by the immune-mediated destruction of intra-hepatic bile ducts. The autoimmune nature of PBC involves humoral and cell-mediated responses that target endogenous mitochondrial proteins. It is thought that the breakdown of...

Spring 2011

De Souza, Andrea

The proteome, a hybrid term from protein and genome, is the total set of proteins expressed by a genome in a cell, tissue, or organism at a given time. Proteomics, the study of the proteome, is concerned with a variety of topics such as identity, quantity, activity, structure, protein-protein...

Fall 2013

Chen, Lu

Mass spectrometry (MS) is widely used in proteomic work for protein identification and characterization. A key to the success of MS for protein analysis is related to sample preparation. Current sample preparation methods do not meet all the needs of protein or proteome analysis. My thesis work...