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Fall 2020

Alolayan, Waad Riyad

Background Head and neck cancer treatments have been showing promising outcomes, yet they often have significant impact on patients. With an approximate 50% survival rate, individuals with a history of this type of cancer are living with long term challenges. With the increasing focus on...

Spring 2013

Campbell, Stuart D.

Polycomb protein methyltransferase, Enhancer of Zeste 2 (Ezh2), is frequently overexpressed in human malignancy and is implicated in cancer cell proliferation and invasion. Recently, several other polycomb proteins have been implicated in modulating the response to DNA double strand breaks, and...

Fall 2015

Hodge, Curtis D

DNA is a detailed layout of instructions for cellular function. The integrity of human DNA is constantly challenged by a barrage of exogenous and endogenous sources. A regime of genome stability maintenance has evolved to repair the many different types of DNA damage. A form of communication...

Spring 2017

Ebadi, Maryam

During cancer progression, many patients will experience some degree of wasting of both muscle and adipose tissue. However, little is-known about adipose tissue alterations after a cancer diagnosis. Therefore, this research was conducted to first understand the prognostic significance of adipose...

Fall 2016

Gushue, Danielle L

Antemortem identification of Creutzfeldt-Jakob disease (CJD) patients is initially based upon clinical presentation of the disease. Symptoms are assessed in combination with results from cerebrospinal fluid (CSF) analysis, electroencephalography (EEG), magnetic resonance imaging (MRI), and...

Spring 2020

Nami Mollalou, Babak

HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...

Fall 2009

Bowker, Samantha Lyndsey

There is substantial evidence of the elevated risk of cancer among individuals with type 2 diabetes. Very little is known, however, about the role that antidiabetic therapies play in this relationship. The objective of this program of research was to examine whether there is a therapeutic risk...

Fall 2010

Moroz, Jennifer

The goal of this study was to show that quantifiable metabolic changes may be used to screen for cancer. NIH III nude mice (n=22) were injected with human GBM cells, with daily urine samples collected pre and post-injection. 14 mice were injected with saline to serve as controls. The...

Fall 2012

Craik, Alison C

Taxane chemotherapy is widely used in the treatment of breast cancer. Despite its widespread clinical use, the molecular mechanisms of paclitaxel induced apoptosis remain unclear. Our laboratory has identified an important role for the BH3-only protein, BAD, in the paclitaxel induced cell death...

Fall 2018

Mansour, Sola

Background: Cancer-associated venous thromboembolism (VTE) is associated with significant morbidity and mortality. Cancer patients are at higher risk of VTE recurrence despite anticoagulation and bleeding complications while on anticoagulation. There are some risk factors of bleeding specific...