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2015-10-26

Arantes, Adriano S., Coros, Colin, Moore, Stephen, Liao, Xiaoping, Crowley, John J., Sargolzaei, Mehdi, Miller, Stephen P., Schenkel, Flavio, Stothard, Paul, Basarab, John A., De Pauw, Mary, Plastow, Graham S.

Background The Canadian Cattle Genome Project is a large-scale international project that aims to develop genomics-based tools to enhance the efficiency and sustainability of beef and dairy production. Obtaining DNA sequence information is an important part of achieving this goal as it...

2003

Day, Andy E., Andersson, Leif, Plastow, Graham S., Pielberg, Gerli

Gene duplications are common in the vertebrate genome, and duplicated loci often show a variation in copy number that may have important phenotypic effects. Here we describe a powerful method for quantification of duplicated copies based on pyrosequencing. A reliable quantification was obtained...

2016-03-08

Bao, Hua, Schroyen, Martine, Rowland, Robert R.R., Guan, Le L., Stothard, Paul, Reecy, James M., Fritz-Waters, Eric, Koltes, James E., Kommadath, Arun, Plastow, Graham S., Eisley, Christopher, Tuggle, Christopher K. , Dekkers, Jack C.M., Lunney, Joan K., Choi, Igseo

Background A region on Sus scrofa chromosome 4 (SSC4) surrounding single nucleotide polymorphism (SNP) marker WUR10000125 (WUR) has been reported to be strongly associated with both weight gain and serum viremia in pigs after infection with PRRS virus (PRRSV). A proposed causal mutation in the...

2016-01-01

Hess, Andrew S., Islam, Zeenath, Hess, Melanie K., Rowland, Raymond R. R., Lunney, Joan K., Doeschl-Wilson, Andrea, Plastow, Graham S., Dekkers, Jack C. M.

Background:Porcine reproductive and respiratory syndrome (PRRS) is one of the most important swine diseases in the world and genetic selection of pigs for increased resistance to PRRS is an attractive method to improve the health status of the swine herd. This study compared phenotypic and...

2016

Ladinig, Andrea, Stothard, Paul, Wilkinson, Jamie M., Kommadath, Arun, Plastow, Graham S., Harding, John C. S., Bao, Hua, Lunney, Joan K.

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant females causes fetal death and increased piglet mortality, but there is substantial variation in the extent of reproductive pathology between individual dams. This study used RNA-sequencing to characterize the whole...

2016-04-19

Wilkinson, Jamie M., Ladinig, Andrea, Bao, Hua, Kommadath, Arun, Stothard, Paul, Lunney, Joan K., Harding, John C. S., Plastow, Graham S.

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnantfemales causes fetal death and increased piglet mortality, but there is substantial variationin the extent of reproductive pathology between individual dams. This study used RNA-sequencing to characterize the whole...

2020-01-01

Bai, Xuechun, Putz, Austin M., Wang, Zhiquan, Fortin, Frederic, Harding, John C. S., Dyck, Michael K., Dekkers, Jack C. M., Field, Catherine J., Plastow, Graham S., PigGen Canada

Disease resilience is a valuable trait to help manage infectious diseases in livestock. It is anticipated that improved disease resilience will sustainably increase production efficiency, as resilient animals maintain their performance in the face of infection. The objective of this study was to...

2016-01-01

Serao, Nick V. L., Kemp, Robert A., Mote, Benny E., Willson, Philip, Harding, John C. S., Bishop, Stephen C., Plastow, Graham S., Dekkers, Jack C. M.

Background:Our recent research showed that antibody response to porcine reproductive and respiratory syn-drome (PRRS), measured as sample-to-positive (S/P) ratio, is highly heritable and has a high genetic correlation with reproductive performance during a PRRS outbreak. Two major quantitative...

2017-04-10

Kommadath, Arun, Bao, Hua, Choi, Igseo, Reecy, James M., Koltes, James E., Fritz-Waters, Elyn, Eisley, Chris J., Grant, Jason R., Rowland, Robert R. R., Tuggle, Christopher K., Dekkers, Jack C. M., Lunney, Joan K., Guan, Le Luo, Stothard, Paul, Plastow, Graham S.

It has been shown that inter-individual variation in host response to porcine reproductive and respiratory syndrome (PRRS) has a heritable component, yet little is known about the underlying genetic architecture of gene expression in response to PRRS virus (PRRSV) infection. Here, we integrated...

2016

Ladinig, Andrea, Stothard, Paul, Bao, Hua, Hong, Linjun, Lunney, Joan K., Harding, John C. S., Wilkinson, Jamie M., Plastow, Graham S.

Background Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant pigs can result in congenital infection and ultimately fetal death. Little is known about immune responses to infection at the maternal-fetal interface and in the fetus itself, or the molecular events...