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2013-02-04

Hamm, Michele, Vandermeer, Ben, Thomson, Denise, Milne, Andrea, Tjosvold, Lisa, Klassen, Terry P., Curtis, Sarah, Hartling, Lisa

BACKGROUND: Randomized controlled trials (RCTs) are the gold standard for trials assessing the effects of therapeutic interventions; therefore it is important to understand how they are conducted. Our objectives were to provide an overview of a representative sample of pediatric RCTs published in...

2013-02-04

Hartling, Lisa, Chisholm, Annabritt, Moher, David, Bow, Simon, Klassen, Terry P., Thomson, Denise, Tjosvold, Lisa, Klassen, Jeffrey

Background: Systematic reviews (SRs) are considered an important tool for decision-making. There has been no recent comprehensive identification or description of child-relevant SRs. A description of existing child-relevant SRs would help to identify the extent of available child-relevant...

2008

Hartling, Lisa, Tjosvold, Lisa, Klassen, Terry P.

An overview of the development of a pediatric controlled trials register, the World's most comprehensive register of published pediatric trials.

2013-02-15

Klassen, Terry P., Plint, Amy C., Vandermeer, Ben, Tjosvold, Lisa, Hartling, Lisa, Fernandes, Ricardo M., Patel, Hema, Bialy, Liza M., Johnson, David W.

Background: Bronchodilators are commonly used for acute bronchiolitis, despite uncertain effectiveness. Objectives: To examine the efficacy and safety of epinephrine in children less than two with acute viral bronchiolitis. Search methods: We searched CENTRAL (2010, Issue 3) which contains the...

2013-02-15

Tjosvold, Lisa, Klassen, Terry P., Bialy, Liza M., Hartling, Lisa, Vandermeer, Ben, Johnson, David W., Patel, Hema, Plint, Amy C., Fernandes, Ricardo M.

BACKGROUND: Previous systematic reviews have not shown clear benefit of glucocorticoids for acute viral bronchiolitis, but their use remains considerable. Recent large trials add substantially to current evidence and suggest novel glucocorticoid-including treatment approaches. OBJECTIVES: To...

2013-02-15

Joffe, Ari, Vandermeer, Ben, Hartling, Lisa, Lequier, Laurance, Larsen, Bodil, Anton, Natalie, Tjosvold, Lisa

Background: Nutritional support in the critically ill child has not been well investigated and is a controversial topic within paediatric intensive care. There are no clear guidelines as to the best form or timing of nutrition in critically ill infants and children. Objectives: To assess the...