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2012

Guan, Leluo, Romao, Josue M., McAllister, Tim, He, Maolong, Jin, Weiwu

Background MicroRNAs (miRNAs) are a class of molecular regulators found to participate in numerous biological processes, including adipogenesis in mammals. This study aimed to evaluate the differences of miRNA expression between bovine subcutaneous (backfat) and visceral fat depots (perirenal...

2011

Toullec, Jean-Yves, Meng, Yan, Guan, Leluo, Clark, Melody S., Moore, Stephen S., Thorne, Michael A. S., Peck, Lloyd S.

Background The Antarctic krill Euphausia superba is a keystone species in the Antarctic food chain. Not only is it a significant grazer of phytoplankton, but it is also a major food item for charismatic megafauna such as whales and seals and an important Southern Ocean fisheries crop. Ecological...

2001

Guan, Leluo, Kamino, Kei

Background Oceans are iron-deficient and nutrient-poor environments. These conditions impart limitations on our understanding of and our ability to identify microorganisms from the marine environment. However, less of knowledge on the influence of siderophores and N-acyl homoserinelactone as...

2009

Grant, Jason, Stothard, Paul, Moore, Stephen S., Guan, Leluo, Jin, Weiwu

Background MicroRNAs (miRNAs) are a family of ~22 nucleotide small RNA molecules which regulate gene expression by fully or partially binding to their complementary sequences in mRNAs or promoters. A large number of miRNAs and their expression patterns have been reported in human, mouse and rat....

2004

Kamiya, Nobuo , Tsujimoto, Gozoh, Kawano, Yoshiaki, Yaguma, Kouji, Guan, Leluo, Sugiura, Yukio, Matsumoto, Osamu

Crystals of the self-complementary oligonucleotide d(CCAGG­CCTGG) [Heinemann & Alings (1989), J. Mol. Biol. 210, 369-381] complexed with the hydroperoxide of cobalt-pepleomycin (CoPEP) were obtained by the hanging-drop vapour-diffusion method at 298 K. An X-ray diffraction data set was collected...

2013

Jin, Weiwu, He, Maolong, Guan, Leluo, Romao, Josue M., McAllister, Tim

Adipose tissue plays a critical role in energy homeostasis and metabolism. There is sparse understanding of the molecular regulation at the protein level of bovine adipose tissues, especially within different fat depots under different nutritional regimes. The objective of this study was to...

2014

David, Joel, De Buck, Jeroen, Barkema, Herman W., Guan, Leluo

Early detection of Johne's disease (JD) caused by Mycobacterium avium subspecies paratuberculosis (MAP) is essential to reduce transmission; consequently, new diagnostic techniques and approaches to detect MAP or markers of early MAP infection are being explored. The objective was to identify...

2009

Fernyhough, Melinda E., Hausman, Gary J., Guan, Leluo, Guridi, Maitea, Jiang, Zhihua, Dodson, Michael V., Chen, Jie

Clonal cultures of pig-derived mature adipocytes are capable of dedifferentiating and forming proliferative-competent progeny cells in vitro. Initial lipid processing, is different to that observed in cultures of beef-derived adipocytes. Mature pig adipocytes extrude lipid before proliferation,...

2011

Williams, John L., Moore, Stephen S., Almeida, Luciane M., Basu, Urmila, Guan, Leluo

Bovine spongiform encephalopathy (BSE) is a fatal disorder in cattle characterized by progressive neurodegeneration of the central nervous system. We investigated the molecular mechanisms involved in neurodegeneration during prion infection through the identification of genes that are...

2014

Jin, Weiwu, He, Maolong, Guan, Leluo, Romao, Josue M., McAllister, Tim

Background MicroRNAs (miRNAs) are small non-coding RNAs found to regulate several biological processes including adipogenesis. Understanding adipose tissue regulation is critical for beef cattle as fat is an important determinant of beef quality and nutrient value. This study analyzed the...