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Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
Download2008-03-13
Al-Attar, Salam A., Pollex, Rebecca L., Ban, Matthew R., Young, T. Kue, Bjerregaard, Peter, Anand, Sonia S., Yusuf, Salim, Zinman, Bernard, Harris, Stewart B., Hanley, Anthony J. G., Connelly, Philip W., Huff, Murray W., Hegele, Robert A.
"Background: The rs9939609 T>A single-nucleotide polymorphism (SNP) in the FTO gene has previously been found to be associated with obesity in European Caucasian samples. The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in...
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2008-12-01
Kelly, Janet, Lanier, Anne, Santos, Maria, Healey, Sylvia, Louchini, Rabia, Friborg, Jeppe, Young, T. Kue
"Objectives: This is first of 2 papers on the Circumpolar Inuit Cancer Review, an international collaborative effort involving researchers and health officials from Alaska, Canada and Greenland. It covers the period 1989–2003, updating the last review (1969-1988) and together provides an overview...
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Cardiovascular Risk According to Plasma Apolipoprotein and Lipid Profiles in a Canadian First Nation
Download2011
Riediger, Natalie D., Bruce, Sharon G., Young, T. Kue
"Introduction: Despite high diabetes rates among Canadian First Nations people, little is known about their cardiovascular disease risk. Our aim was to describe the apolipoprotein profile with respect to cardiovascular risk in a Canadian First Nation community. Methods: In 2003, a representative...
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2001-06-01
Hegele, Robert A., Huff, Murray W., Young, T. Kue
"We discovered that rare mutations in LMNA, which encodes lamins A and C, underlie autosomal dominant Dunnigan-type familial partial lipodystrophy. Because familial partial lipodystrophy is an extreme example of genetically disturbed adipocyte differentiation, it is possible that common variation...
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Dietary correlates of an at-risk BMI among Inuit adults in the Canadian high arctic: cross-sectional international polar year Inuit health survey, 2007-2008
Download2012-09-18
Zienczuk, Natalia, Young, T. Kue, Cao, Zhirong R., Egeland, Grace M.
"Background: The study’s objective was to investigate the dietary correlates of an at-risk body mass index (BMI) among Inuit adults from thirty-six communities across the Canadian Arctic using data from the cross-sectional International Polar Year Inuit Health Survey, conducted in 2007–2008....
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Emerging obesity among preschool-aged Canadian Inuit children: results from the Nunavut Inuit Child Health Survey
Download2010-04-26
Galloway, Tracey, Young, T. Kue, Egeland, Grace M.
"Objectives: The study goal was to evaluate the growth status of preschool-age Canadian Inuit children. Study design: As part of a larger study of population health across the Canadian High Arctic, the International Polar Year Inuit Health Survey collected growth and nutrition data on 388...
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Ethnic and Regional Differences in Prevalence and Correlates of Chronic Diseases and Risk Factors in Northern Canada
Download2010
Sarkar, Joykrishna, Lix, Lisa M., Bruce, Sharon, Young, T. Kue
"Introduction: We investigated ethnic and geographic variations in major chronic diseases and risk factors in northern Canada, an area that is undergoing rapid changes in its social, cultural, and physical environments. Methods: Self-report data were obtained from the population-based Canadian...
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Exclusive Breastfeeding among Canadian Inuit: Results from the Nunavut Inuit Child Health Survey
Download2014-04-15
McIsaac, Kathryn E., Lou, Wendy, Sellen, Daniel, Young, T. Kue
"Background: Very little population-based research has been conducted around the exclusive breastfeeding practices of Inuit Canadians. Objectives: This research aims to assess the distribution of exclusive breastfeeding among Inuit Canadians and to identify factors associated with exclusive...
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1999-08-04
Hegele, Robert A., Anderson, Carol, Young, T. Kue, Connelly, Philip W.
"The GNB3 825T allele encodes a product that has enhanced activation of heterotrimeric G proteins in vitro and could play a role in adipogenesis. We therefore evaluated the possibility that the GNB3 825T allele was associated with obesity in a sample of 213 healthy Canadian Inuit. We found that...
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2009-05-28
Fergenbaum, Jennifer H., Bruce, Sharon, Lou, Wendy, Hanley, Anthony J.G., Greenwood, Carol, Young, T. Kue
"The association between obesity, other cardiovascular risk factors, and cognitive function in a Canadian First Nations population was investigated using a cross‐sectional design. Eligible individuals were aged ≥18 years, without a history of stroke, nonpregnant, with First Nations status, and...