Common Genomic Variation in LMNA Modulates Indexes of Obesity in Inuit

  • Author(s) / Creator(s)
  • "We discovered that rare mutations in LMNA, which encodes lamins A and C, underlie autosomal dominant Dunnigan-type familial partial lipodystrophy. Because familial partial lipodystrophy is an extreme example of genetically disturbed adipocyte differentiation, it is possible that common variation in LMNA is associated with obesity-related phenotypes. We subsequently discovered a common single nucleotide polymorphism (SNP) in LMNA, namely 1908C/T, which was associated with obesity-related traits in Canadian Oji-Cree." (as cited in abstract)

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    Article (Published)
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    Attribution 4.0 International
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  • Citation for previous publication
    • Hegele, R. A., Huff, M. W., & Young, T. K. (2001). Common genomic variation in LMNA modulates indexes of obesity in Inuit. Journal of Clinical Endocrinology and Metabolism, 86(6), 2747-2751.
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