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Common Genomic Variation in LMNA Modulates Indexes of Obesity in Inuit

  • Author(s) / Creator(s)
  • "We discovered that rare mutations in LMNA, which encodes lamins A and C, underlie autosomal dominant Dunnigan-type familial partial lipodystrophy. Because familial partial lipodystrophy is an extreme example of genetically disturbed adipocyte differentiation, it is possible that common variation in LMNA is associated with obesity-related phenotypes. We subsequently discovered a common single nucleotide polymorphism (SNP) in LMNA, namely 1908C/T, which was associated with obesity-related traits in Canadian Oji-Cree." (as cited in abstract)

  • Date created
    2001-06-01
  • Subjects / Keywords
  • Type of Item
    Article (Published)
  • DOI
    https://doi.org/10.7939/r3-jm95-e603
  • License
    Attribution 4.0 International
  • Language
  • Citation for previous publication
    • Hegele, R. A., Huff, M. W., & Young, T. K. (2001). Common genomic variation in LMNA modulates indexes of obesity in Inuit. Journal of Clinical Endocrinology and Metabolism, 86(6), 2747-2751. https://doi.org/10.1210/jcem.86.6.7550
  • Source
    <https://academic.oup.com/jcem/article/86/6/2747/2849133>
  • Link to related item
    <https://v2.sherpa.ac.uk/id/publication/26766>