Common Genomic Variation in LMNA Modulates Indexes of Obesity in Inuit

• Author(s) / Creator(s)

  • Hegele, Robert A.
  • Huff, Murray W.
  • Young, T. Kue

• "We discovered that rare mutations in LMNA, which encodes lamins A and C, underlie autosomal dominant Dunnigan-type familial partial lipodystrophy. Because familial partial lipodystrophy is an extreme example of genetically disturbed adipocyte differentiation, it is possible that common variation in LMNA is associated with obesity-related phenotypes. We subsequently discovered a common single nucleotide polymorphism (SNP) in LMNA, namely 1908C/T, which was associated with obesity-related traits in Canadian Oji-Cree." (as cited in abstract)

• Date created

  2001-06-01

• Subjects / Keywords

  • Obesity
  • Inuit
  • Canada

• Type of Item

  Article (Published)

• DOI

  https://doi.org/10.7939/r3-jm95-e603

• License

  Attribution 4.0 International