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Common Genomic Variation in LMNA Modulates Indexes of Obesity in Inuit
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- Author(s) / Creator(s)
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"We discovered that rare mutations in LMNA, which encodes lamins A and C, underlie autosomal dominant Dunnigan-type familial partial lipodystrophy. Because familial partial lipodystrophy is an extreme example of genetically disturbed adipocyte differentiation, it is possible that common variation in LMNA is associated with obesity-related phenotypes. We subsequently discovered a common single nucleotide polymorphism (SNP) in LMNA, namely 1908C/T, which was associated with obesity-related traits in Canadian Oji-Cree." (as cited in abstract)
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- Date created
- 2001-06-01
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- Type of Item
- Article (Published)
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- License
- Attribution 4.0 International