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Skip to Search Results- 17Harding, John C. S.
- 13Plastow, Graham S.
- 9Bao, Hua
- 9Stothard, Paul
- 8Liang, Guanxiang
- 7Lunney, Joan K.
- 18PigGen Canada
- 18PigGen Canada/Journal Articles
- 6Agricultural, Food and Nutritional Science, Department of
- 6Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 4Roy Berg Kinsella Research Ranch
- 4Roy Berg Kinsella Research Ranch/Journal Articles (Kinsella Ranch)
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Bioinformatic analyses in early host response to Porcine Reproductive and Respiratory Syndrome virus PRRSV reveals pathway differences between pigs with alternate genotypes for a major host response QTL
Download2016-03-08
Bao, Hua, Schroyen, Martine, Rowland, Robert R.R., Guan, Le L., Stothard, Paul, Reecy, James M., Fritz-Waters, Eric, Koltes, James E., Kommadath, Arun, Plastow, Graham S., Eisley, Christopher, Tuggle, Christopher K. , Dekkers, Jack C.M., Lunney, Joan K., Choi, Igseo
Background A region on Sus scrofa chromosome 4 (SSC4) surrounding single nucleotide polymorphism (SNP) marker WUR10000125 (WUR) has been reported to be strongly associated with both weight gain and serum viremia in pigs after infection with PRRS virus (PRRSV). A proposed causal mutation in the...
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Comparative transcriptomic analysis of rectal tissue from beef steers revealed reduced host immunity in Escherichia coli O157:H7 super-shedders
Download2016-03-09
McAllister, Tim A., Wang, Ou, Plastow, Graham, Stanford, Kim, Liang, Guanxiang, Guan, Le L., Selinger, Brent
Super-shedder cattle are a major disseminator of E. coli O157:H7 into the environment, and the terminal rectum has been proposed as the primary E. coli O157:H7 colonization site. This study aimed to identify host factors that are associated with the super-shedding process by comparing...
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Differences in whole blood gene expression associated with infection time-course and extent of fetal mortality in a reproductive model of type 2 porcine reproductive and respiratory syndrome virus (PRRSV) infection
Download2016
Ladinig, Andrea, Stothard, Paul, Wilkinson, Jamie M., Kommadath, Arun, Plastow, Graham S., Harding, John C. S., Bao, Hua, Lunney, Joan K.
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant females causes fetal death and increased piglet mortality, but there is substantial variation in the extent of reproductive pathology between individual dams. This study used RNA-sequencing to characterize the whole...
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Differences in Whole Blood Gene ExpressionAssociated with Infection Time-Course andExtent of Fetal Mortality in a ReproductiveModel of Type 2 Porcine Reproductive andRespiratory Syndrome Virus (PRRSV)Infection
Download2016-04-19
Wilkinson, Jamie M., Ladinig, Andrea, Bao, Hua, Kommadath, Arun, Stothard, Paul, Lunney, Joan K., Harding, John C. S., Plastow, Graham S.
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnantfemales causes fetal death and increased piglet mortality, but there is substantial variationin the extent of reproductive pathology between individual dams. This study used RNA-sequencing to characterize the whole...
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Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infection
Download2020-01-01
Van Goor, Angelica, Pasternak, Alex, Walker, Kristen, Hong, Linjun, Malgarin, Carolina, MacPhee, Daniel J., Harding, John C. S., Lunney, Joan K.
Background:A pregnant gilt infected with porcine reproductive and respiratory syndrome virus (PRRSV) can transmit the virus to her fetuses across the maternal-fetal-interface resulting in varying disease outcomes. However,the mechanisms leading to variation in fetal outcome in response to PRRSV...
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Exploring Phenotypes for Disease Resilience in Pigs Using Complete Blood Count Data From a Natural Disease Challenge Model
Download2020-01-01
Bai, Xuechun, Putz, Austin M., Wang, Zhiquan, Fortin, Frederic, Harding, John C. S., Dyck, Michael K., Dekkers, Jack C. M., Field, Catherine J., Plastow, Graham S., PigGen Canada
Disease resilience is a valuable trait to help manage infectious diseases in livestock. It is anticipated that improved disease resilience will sustainably increase production efficiency, as resilient animals maintain their performance in the face of infection. The objective of this study was to...
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Fetal Metabolomic Alterations Following Porcine Reproductive and Respiratory Syndrome Virus Infection
Download2020-12-11
Malgarin, Carolina M., MacPhee, Daniel J., Harding, John C. S.
PRRSV infection in third-trimester pregnant sows can lead to fetal death and abortions, although the mechanisms triggering these effects are not well understood. Since resistant and susceptible fetuses can coexist in the same litter, we propose that there may be differential mechanisms used by...
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Genetic and genomic basis of antibody response to porcine reproductive and respiratory syndrome (PRRS) in gilts and sows
Download2016-01-01
Serao, Nick V. L., Kemp, Robert A., Mote, Benny E., Willson, Philip, Harding, John C. S., Bishop, Stephen C., Plastow, Graham S., Dekkers, Jack C. M.
Background:Our recent research showed that antibody response to porcine reproductive and respiratory syn-drome (PRRS), measured as sample-to-positive (S/P) ratio, is highly heritable and has a high genetic correlation with reproductive performance during a PRRS outbreak. Two major quantitative...
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Genetic architecture of gene expression underlying variation in host response to porcine reproductive and respiratory syndrome virus infection
Download2017-04-10
Kommadath, Arun, Bao, Hua, Choi, Igseo, Reecy, James M., Koltes, James E., Fritz-Waters, Elyn, Eisley, Chris J., Grant, Jason R., Rowland, Robert R. R., Tuggle, Christopher K., Dekkers, Jack C. M., Lunney, Joan K., Guan, Le Luo, Stothard, Paul, Plastow, Graham S.
It has been shown that inter-individual variation in host response to porcine reproductive and respiratory syndrome (PRRS) has a heritable component, yet little is known about the underlying genetic architecture of gene expression in response to PRRS virus (PRRSV) infection. Here, we integrated...
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Genome-wide analysis of the transcriptional response to porcine reproductive and respiratory syndrome virus infection at the maternal/fetal interface and in the fetus
Download2016
Ladinig, Andrea, Stothard, Paul, Bao, Hua, Hong, Linjun, Lunney, Joan K., Harding, John C. S., Wilkinson, Jamie M., Plastow, Graham S.
Background Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant pigs can result in congenital infection and ultimately fetal death. Little is known about immune responses to infection at the maternal-fetal interface and in the fetus itself, or the molecular events...