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Skip to Search Results- 238Chemistry, Department of
- 227Chemistry, Department of/Journal Articles (Chemistry)
- 11Chemistry, Department of/Research Data and Materials (Chemistry)
- 1Human Ecology, Department of
- 1Human Ecology, Department of/Journal Articles (Human Ecology)
- 1Electrical and Computer Engineering, Department of
- 69Klassen, John S.
- 54Serpe, Michael J.
- 52Kitova, Elena N.
- 18Michaelis, V.K.
- 17Gao, Yongfeng
- 14Loppnow, Glen R.
- 20Electrospray ionization mass spectrometry
- 14Etalons
- 13SSNMR
- 12Affinity
- 12Stimuli-Responsive Polymers
- 11Complexes
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2015
Li, Xue, Serpe, Michael J., Gao, Yongfeng
Responsive polymer-based materials (or smart materials) have found numerous uses over the years due to their ease of synthesis and various responsivities/functionalities. Of them, stimuli-responsive hydrogel particles (microgels) have generated a lot of interest, and have been used for a number...
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2017-01-01
Gao, Yongfeng, Wei, Menglian, Li, Xue, Xu, Wenwen, Ahiabu, Andrews, Perdiz, Juliana, Liu, Zining, Serpe, Michael J.
Stimuli-responsive polymers are capable of changing their chemical and/or physical properties in response to environmental stimuli. This unique feature has allowed stimuli-responsive polymers to be used in a variety of applications. In this review, we present a basic introduction to the theories...
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Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases
Download2009
Abbott, D. W., Boraston, Alisdair B. , Vocadlo, David J., Macauley, Matthew S.
Endo-β-d-glucosaminidases from family 85 of glycoside hydrolases (GH85 endohexosaminidases) act to cleave the glycosidic linkage between the two N-acetylglucosamine units that make up the chitobiose core of N-glycans. Endohexosaminidase D (Endo-D), produced by Streptococcus pneumoniae, is...
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2004
Okon, Mark, Schulman, Brenda A., Macauley, Matthew S., McIntosh, Lawrence P., Mackereth, Cameron D., Schärpf, Manuela, Errington, Wesley J.
Although sumoylation regulates a diverse and growing number of recognized biological processes, the molecular mechanisms by which the covalent attachment of the ubiquitin-like protein SUMO can alter the properties of a target protein remain to be established. To address this question, we have...
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Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile
Download2014
Ng, Kenneth K. S., Tanha, Jamshid, Kitova, Elena N., Eugenio, Luiz, Murase, Tomohiko, Klassen, John S., Hussack, Greg, Schorr, Melissa
Clostridium difficile infection is a serious and highly prevalent nosocomial disease in which the two large, Rho-glucosylating toxins TcdA and TcdB are the main virulence factors. We report for the first time crystal structures revealing how neutralizing and non-neutralizing single-domain...
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Structure and stability of carbohydrate-lipid interactions: Methylmannose polysaccharide-fatty acid complexes
Download2016
Klassen, John S., Siuda, Iwona, Renaud, Justin, Tieleman, D. Peter, Kitova, Elena N., Liu, Lan, Mayer, Paul M., Richards, Michele R., Lowary, Todd L.
We report a detailed study of the structure and stability of carbohydrate–lipid interactions. Complexes of a methylmannose polysaccharide (MMP) derivative and fatty acids (FAs) served as model systems. The dependence of solution affinities and gas-phase dissociation activation energies (Ea) on FA...
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Structure and stability of carbohydrate-lipid interactions: Methylmannose polysaccharide-fatty acid complexes
Download2016
Mayer, Paul M., Richards, Michele R., Lowary, Todd L., Renaud, Justin, Klassen, John S., Tieleman, D. Peter, Kitova, Elena N., Liu, Lan, Siuda, Iwona
We report a detailed study of the structure and stability of carbohydrate–lipid interactions. Complexes of a methylmannose polysaccharide (MMP) derivative and fatty acids (FAs) served as model systems. The dependence of solution affinities and gas-phase dissociation activation energies (Ea) on FA...
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2017-01-01
Xu, Wenwen, Song, Qiao, Xu, Jiang-Fei, Serpe, Michael J., Zhang, Xi
Daily repeated wound dressing changes will lead to additional trauma to newly formed tissue and prolonging the healing process. In this letter, we designed and fabricated an easily removable wound dressing material. To accomplish this, we first generated cross-linkable supramonomers through...
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2016-01-01
Song, Qiao, Gao, Yongfeng, Xu, Jiang-Fei, Qin, Bo, Serpe, Michael J., Zhang, Xi
This letter describes a new method for fabricating supramolecular microgels from supramonomers. To this end, we designed and assembled supramonomers with one acrylate moiety on each end on the basis of noncovalent host–guest interactions, which could be utilized as a cross-linker. Then...
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2015-01-01
Chea, JongMyong, Clive, Derrick L. J.
N-Boc (S)-proline was converted into (2S)-2-[(phenylselanyl)methyl]pyrrolidine which was alkylated on nitrogen with 2-bromo-1-(4-methoxyphenyl)ethan-1-one. Reaction with vinyllithium, 6-exo-trigonal radical cyclization (Bu3SnH, AIBN, PhMe, 110 °C), dehydration (P2O5, H3PO4) and demethylation...