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Fall 2020
Renal autoregulation, comprised of the myogenic response (MR) and the kidney-specific tubuloglomerular feedback (TGF), maintains steady perfusion to the kidneys despite blood pressure fluctuations. The emphasis of this work is on TGF, the dynamics of which generate autonomous oscillations that...
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Tukitaaqtuq (explain to one another, receive explanation from the past) and The Eskimo Identification Canada system
DownloadFall 2014
The government of Canada initiated, implemented, and officially maintained the ‘Eskimo Identification Canada’ system from 1941-1971. With the exception of the Labrador Inuit, who formed the Labrador Treaty of 1765 in what is now called, NunatuKavat, all other Canadian Inuit peoples were issued a...
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Fall 2011
Cancer is one of the major causes of death in the world. In the field of Oncology, clinical trials form the crux of medical effort to find better treatment schedules. These trials are expensive, time consuming, and carry great risks for the patients involved. Mathematical models provide a...
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Spring 2010
Glioma is one of the most challenging types of brain tumors to be treated or controlled locally. One of the main problems is to determine which areas of the apparently normal brain contain glioma cells, as gliomas are known to infiltrate several centimetres beyond the clinically apparent...
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Tumor necrosis factor triggers the expression and activation of matrix metalloproteinases through NADPH-dependent superoxide production
DownloadSpring 2010
Tumor necrosis factor (TNF) is upregulated in a number of cardiomyopathies. This thesis investigates TNF in triggering the expression and activation of matrix metalloproteinases (MMPs) in pressure overload cardiac disease, and explores the role of superoxide. Cardiac pressure overload was...