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Fall 2022

Narayanamurthy, Rukhmani

The obstruction of blood flow to regions of an infant brain leads to a reduction of oxygen and essential nutrients, causing what is known as hypoxic-ischemic (HI) damage to that region. Presently the only treatment available for affected neonates is hypothermia: head or whole-body cooling....

Fall 2015

Bennett, Jeffrey A

Prader-Willi syndrome (PWS) is a genetic disorder caused by the lack of paternal expression from chromosome 15q11-13. The PWS phenotype includes hypotonia and failure to thrive during infancy, followed by hyperphagia, insatiable appetite, cognitive delay, problem behaviors, and social impairments...

Spring 2015

Biffis, Kimberly M

Due to presumed immune immaturity, infants are able to accept heart transplants across the ABO barrier, a procedure that would result in catastrophic consequences if performed in adults. Our group has demonstrated that following ABO-incompatible heart transplantation (ABOi HTx), infants develop...

Fall 2020

Wine, Osnat

Academia has transformed research to be more collaborative to address complex questions such as understanding the relationship between human health and the environment. Such collaborations harness diverse expertise and perspectives of various stakeholders including researchers, practitioners,...

Fall 2015

Corrigan, Jennifer

Introduction Cerebral Palsy (CP) is a ubiquitous term used to describe a group of permanent, non-progressive disorders of movement, posture, and behaviour. Despite countless advances in neonatal medicine, the incidence of CP has remained constant in term infants over the last three decades. More...

Spring 2012

Gao, Xia

ABCG1 mediates cholesterol efflux onto lipidated apolipoprotein A-I and plays an important role in macrophage reverse cholesterol transport, thereby preventing atherosclerosis. However, how ABCG1 mediates cholesterol efflux is unclear. We found that Cys514 located within the third putative...

Fall 2019

Byrne, Nikole

Heart failure (HF) is a condition where the cardiac muscle exhibits contractile dysfunction, limiting its ability to deliver adequate amounts of oxygen to organs throughout the body. Despite improved survival seen with pharmacological and mechanical treatment strategies, HF patients continue to...

Spring 2013

Mabood, Neelam

A ‘safety net’ and a key system entry point to access care for alcohol-related events, the emergency department (ED) can play an important role in the early identification of harmful effects of adolescent alcohol use thus making it crucial to understand the clinical care experiences of pediatric...

Fall 2021

Tun, Mon Hnin

Rising caesarean section (CS) rate remains a public health issue. Induction of labour (IOL) rates have been rising steadily in Canada from 12.9% in 1991 to 21.3% in 2004. Failed IOL occurs in 20% of induced pregnancies and is the major risk factor for CS. The purpose of this study was to...

Spring 2023

Reid, Kyle Burke

Background: The Autism Observation Scale for Infants (AOSI) has been used to investigate early features of children with an increased likelihood (IL) of a later diagnosis of autism spectrum disorder (ASD). Though independent research groups have evaluated its use in IL infant siblings (younger...