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Biochemical Characterization of ATP-Binding Cassette Transporter G1 Mediated Cholesterol Efflux
DownloadSpring 2012
ABCG1 mediates cholesterol efflux onto lipidated apolipoprotein A-I and plays an important role in macrophage reverse cholesterol transport, thereby preventing atherosclerosis. However, how ABCG1 mediates cholesterol efflux is unclear. We found that Cys514 located within the third putative...
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Fall 2015
Phosphatidylethanolamine N-methyltransferase (PEMT), a liver enriched enzyme, is responsible for approximately one third of hepatic phosphatidylcholine (PC) biosynthesis via three sequential methylations of phosphatidylethanolamine (PE). PEMT is also expressed in white adipose tissue (WAT). When...
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