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Skip to Search Results- 2Jutras, Jean-David
- 2Yip, Eugene
- 1Abdou, Ismail
- 1Adamia, Sophia
- 1Alaee, Mahsa
- 1Anderson, Danielle L.
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Fall 2015
With the advent and development of hybrid Linac-MR technology, we will be able to track and treat lesions in real time. This will permit the narrowing of radiotherapy margins and escalation of dose, augmenting the therapeutic outcome of radiotherapy. The addition of a magnetic field to the...
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Dosimetry and Biological Studies for Microbeam Radiation Therapy at the Canadian Light Source
DownloadFall 2015
Microbeam radiation therapy (MRT) is a pre-clinical type of radiation therapy that uses an array of high-dose microbeams to treat solid tumours. An intense, quasi-parallel synchrotron beam is collimated to create microbeams several 10s of μm wide, and separated by 100s of μm. Animal studies...
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Efficient data acquisition, transmission and post-processing for quality spiral Magnetic Resonance Imaging
DownloadFall 2011
Spiral Magnetic Resonance Imaging (MRI) has traditionally presented more technical and computational challenges compared to its traditional Cartesian counterpart, notably a susceptibility to blurring artifacts, especially when scan parameters are non-optimal, and a heavier computational load both...
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Fall 2017
Epidermal Growth Factor-like domain 7 (EGFL7) is a secreted angiogenic factor that is almost exclusively expressed by endothelial cells. High EGFL7 expression occurs during physiological angiogenesis, under pathological conditions, and in solid tumor angiogenesis. Evidence suggests that EGFL7...
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Fall 2022
Dynamic tumour-tracked radiotherapy is a promising method for delivering conformal doses to tumours that exhibit a large degree of motion as a result of patient respiration. However, there exists an inevitable latency between the acquisition of an image of a moving tumour and the adaptation of...
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Fall 2009
One form of protein regulation is accomplished by post-translational modification (PTM). In order to test the importance one type of PTM, methylation, in chromosome segregation, we inhibited protein methylation for brief periods in G2 using the general methylation inhibitor adenosine dialdehyde...
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Fall 2021
Breast cancer is the most common cancer amongst women in Canada. The current treatment regime for early stage breast cancers is breast-conserving surgery with radiation therapy. However, 10-20% of patients develop local recurrence, and some exhibit metastatic spread, which is associated with a...
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Evaluating the consequences of polynucleotide kinase/phosphatase (PNKP) mutations in neurological diseases
DownloadSpring 2022
Genomic stability is extremely important for developing or maintaining normal neurological functions, as the nervous system is constantly suffering from endogenous DNA damage. To maintain such stability, living cells are protected by several different DNA repair pathways. Polynucleotide...
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Evaluation of bioreductively-activated Tirapazamine (TPZ) prodrugs for the management of hypoxic solid tumors
DownloadFall 2019
Solid tumors often have large areas with low levels of oxygen (termed hypoxic regions), which are associated with poor prognosis and treatment response. Tirapazamine (TPZ), a hypoxia targeting anticancer drug, started as a promising candidate to deal with this issue. However, it was withdrawn...
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Evaluation of Hypoxia Induced Regulation of Nucleoside and Amino Acid Membrane Transporters in Breast Cancer
DownloadSpring 2020
Positron Emission Tomography (PET) utilizes radioactively tagged molecules to identify cancerous tissue. In most cases, membrane transporters control entry of these molecules into human cancer cells. Hypoxia-inducible factor (HIF)-1 is the master homeostatic regulator during hypoxia in human...