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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Airo, Adriana M
- 1Arendt, Christopher William.
- 1Awadh, Abdullah
- 1Azaizeh, Bara'ah
- 1Bacik, John-Paul
- 8Evans, David (Medical Microbiology and Immunology)
- 6Foley, Edan (Medical Microbiology and Immunology)
- 5Barry, Michele (Medical Microbiology and Immunology)
- 5Ingham, Robert (Medical Microbiology and Immunology)
- 5Ostergaard, Hanne (Medical Microbiology and Immunology)
- 3Baldwin, Troy (Medical Microbiology and Immunology)
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Thinking inside and outside the blood vessel: S1P-mediated control of vascular tone and the impact of CMV infection
DownloadSpring 2016
Sphingosine 1–phosphate (S1P), a bioactive lipid, has both endothelial barrier enhancing and disrupting effects, but also regulates vascular tone. The concepts of endothelial permeability and vascular tone have traditionally been studied separately. In this thesis, I demonstrate novel findings...
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Fall 2013
Chimpanzees have been previously used to study HAV infection in vivo but they are expensive and difficult to maintain and thus, there is a need for a small animal model. Our aim is to test the susceptibility of the SCID-beige/Alb-uPA mice with chimeric human/mouse livers to HAV infection....
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Fall 2016
Recombination between co-infecting poxviruses provides an important mechanism for generating genetic diversity in the face of selection pressures. However, poxviruses replicate in membrane-bound enclosed cytoplasmic structures known as factories or virosomes that could impede DNA mixing between...
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Fall 2015
Vibrio cholerae is a Gram-negative bacterial species that consists of over 200 serogroups with differing pathogenic potential. Only O1 serogroup strains have been associated with the pandemic spread of cholera, a disease characterized by watery diarrhoea that can lead to severe dehydration and...
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Understanding the function of the JunB transcription factor in anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma
DownloadFall 2013
Anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) is a non-Hodgkin lymphoma thought to arise from an activated T lymphocyte. This lymphoma is characterized by the presence of chromosomal translocations involving the ALK tyrosine kinase, which generate oncogenic...
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Using designed zinc finger proteins to inhibit hepatitis B virus transcription in tissue culture
DownloadFall 2012
Upon infection with hepatitis B virus (HBV) the result will be either a chronic infection or clearance of the virus. For the chronic carriers of HBV, therapy is primarily limited to nucleoside analogs, which inhibits viral replication and prevents production of progeny virus, however the...
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Fall 2014
Smallpox was eradicated using vaccinia viruses (VACV) as vaccines, including Dryvax, a calf-lymph vaccine derived from the New York City Board of Health (NYCBH) strain, and TianTan, a chicken egg cultured vaccine used exclusively in China. To take advantage of the next generation sequencing...
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Vaccinia virus DNA polymerase and ribonucleotide reductase: their role in replication, recombination and drug resistance
DownloadSpring 2010
Despite the eradication of smallpox, poxviruses continue to cause human disease around the world. At the core of poxvirus replication is the efficient and accurate synthesis and repair of the viral genome. The viral DNA polymerase is critical for these processes. Acyclic nucleoside phosphonate...