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Skip to Search Results- 1200Department of Mechanical Engineering
- 364Faculty of Pharmacy and Pharmaceutical Sciences
- 117Department of Biomedical Engineering
- 11Department of Medical Sciences
- 6Department of Electrical and Computer Engineering
- 4Faculty of Medicine
- 2Bhaduri,Swayamdipta
- 2Chini, Seyed Farshid
- 2Gopalakrishnan, K. N.
- 2Hay, Andrew Stuart.
- 2Peck, Bill James
- 2Rahman, Md Mustafizur
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Spring 2019
Over the last few decades the incidence of obesity has increased remarkably in Canada and in the rest of the world, with the highest increases occurring in the excessive weight categories class II (BMI 35– 39.9) and class III (BMI ≥ 40). By 2019, it is anticipated that over 20% of the Canadian...
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16R-HETE and 16S-HETE Alter Human Cytochrome P450 1B1 through Transcriptional and Allosteric Mechanism
DownloadFall 2022
Cardiac hypertrophy is a complex anomaly of the heart associated with increased muscle mass and thickening of the cell walls in response to accumulative stress. Although this condition occurs naturally, the prolonged state will progress into heart failure or even cause death. Recent studies have...
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Fall 2020
This thesis describes the research and development process in creating a 3D ultrasound-based navigation system to assist screw insertion for scoliosis surgery, with a focus on children who have adolescent idiopathic scoliosis (AIS). Screw placement accuracy is critical to prevent spinal cord or...
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4-aminobenzoic acid hydrazide mediated inhibition of Microperoxidase-11: catalytic inhibition by reactive metabolites.
DownloadFall 2011
Currently, there is lack of clinical therapeutics for inhibiting myeloperoxidase mediated pathogenesis. We used 4-aminobenzoic acid hydrazide (4-ABAH), the most potent irreversible inhibitor of myeloperoxidase and microperoxidase-11 to obtain mechanistic insight on the role of reactive...
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A Coarse-Grained Simulation Framework to Study Polyethylenimine-DNA Nanoparticles in Gene Delivery
DownloadSpring 2022
Cellular DNAs contain genetic information vital for the functioning of the cells. Corruption of this information, or genetic disorders, can lead to various diseases. A potential treatment is to deliver exogenous DNAs with the correct genetic information to malignant cells to achieve a...