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Fall 2016

James, Kevin

Reovirus is a naturally benign virus that preferentially replicates in transformed cells and is currently undergoing clinical trials as a promising oncolytic therapy. In normal mouse fibroblasts, transformation by constitutively activated Ras oncogene is sufficient to promote reovirus infection....

Fall 2015

Kostiuk, Tyler T.

Reoviruses have been shown to infect a very broad range of mammalian sources and infections in humans have been associated with gastrointestinal and respiratory illnesses. While the presence of reovirus in several different water matrices and clinical samples has been reported, the clinical...

Fall 2018

Mohamed, Adil SG

Mammalian orthoreovirus (reovirus) is a non-pathogenic virus that naturally infects through the enteric and respiratory routes. Reoviruses are non-enveloped and have a 10-segment double stranded RNA (dsRNA) genome encased in 2 concentric capsid shells. Representative isolates of each of the 3...

Fall 2024

Baabdulla, Arwa Abdulla

In this thesis, we explore the spatial dynamics of viral infection within tissue through mathematical modelling, aiming to understand the impact of virus spread on both cancerous and healthy tissue. Specifically, we investigate how spatial patterning and heterogeneity influence viral infection...

Spring 2020

Yip, Wan Kong

Wild-type mammalian orthoreoviruses (reoviruses) are non-pathogenic viruses infecting hosts via the respiratory and enteric tracts. There are four prototype reovirus strains: the Type 1 Lang (T1L), Type 2 Jones (T2J), Type 3 Abney (T3A), Type 3 Daring (T3D) and Type 4 Ndelle (T4N). A...