Search
Skip to Search Results-
Fall 2012
In this dissertation, I discuss several important problems in the area of bio-relation discovery (BRD). Discovering bio-relations is an important problem that arises frequently in bioinformatics. It involves identifying relationships (usually pairwise) between bio-entities. These relationships...
-
Detecting, correcting, and preventing the batch effects in multi-site data, with a focus on gene expression Microarrays
DownloadSpring 2014
Gene expression microarrays are widely used to better understand the complex biological mechanisms inside cells. One of the main obstacles of applying statistical learning algorithms to microarray data is the large gap between the number of features (p) and the number of available instances (n),...
-
Estimating the Overlap of Top Instances in Lists Ranked by Correlation to Label
Spring 2012
Recent advances in high-throughput technologies, such as genome-wide SNP analysis and microar- ray gene expression profiling, have led to a multitude of ranked lists, where the features (SNPs, genes) are sorted based on their individual correlation with a phenotype. Multiple reviews have shown...
-
Genetic Analysis of Lignification and Secondary Wall Development in Bast Fibers of Industrial Hemp (Cannabis sativa)
DownloadSpring 2010
Industrial hemp (Cannabis sativa) is a highly productive crop that is well suited to cultivation in Canada. To better understand the development of bast (phloem) fiber secondary walls and to facilitate reverse genetics screening for improved germplasm, I undertook two sets of microarray...
-
Fall 2014
The growth of Listeria monocytogenes and spoilage microorganisms is a concern in sodium-reduced ready-to-eat (RTE) meats. To assess the microbial risk of sodium-reduced RTE meats, the microbiota of retail RTE meats was profiled and the growth of L. monocytogenes and an autochthonous microbiota...
-
Fall 2017
The two types of rejection identified in the Banff histopathologic diagnosis are T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR). TCMR is most common early post-transplant while ABMR is the main cause of late graft loss. Kidney transplant TCMR is diagnosed histologically...
-
Fall 2013
Cancer cachexia is a multifactorial syndrome characterized by involuntary weight loss, wasting of skeletal muscle driven by reduced food intake and abnormal metabolism. Cachexia has a negative impact on quality of life, response to chemotherapy and survival. Cachexia research is undeveloped with...
-
Transcriptome and Proteome Based Survey to Identify Aluminum-Responsive Genes in Roots of Arabidopsis Thaliana
DownloadSpring 2010
Aluminum (Al)stress is a major limitation to crop productivity on acidic soils. To help understand the cellular mechanisms underlying the toxicity and resistance of plants to Al, this thesis involved a large-scale, transcriptomic and proteomic analysis of roots of Arabidopsis thaliana and reports...