Search
Skip to Search Results- 1Bhura-Bandali, Farah.
- 1Campeau, Leah L
- 1Dasgupta, Bonnie.
- 1Dennis, J.J.
- 1Dennis, Jonathan J.
- 1Déry, René
-
Toward Modern Inhalational Bacteriophage Therapy: Nebulization of Bacteriophages of Burkholderia cepacia Complex
Download2008
Dennis, Jonathan J., Finlay, Warren H., Golshani, Laleh, Seed, Kimberley D.
Antibiotic-resistant bacterial infections have renewed interest in finding substitute methods of treatment. The purpose of the present in vitro study was to investigate the possibility of respiratory delivery of a Burkholderia cepacia complex (BCC) bacteriophage by nebulized aerosol...
-
Expression and functional significance of the cystic fibrosis transmembrane conductance regulator (CFTR) in human mast cells
DownloadFall 2009
Mast cells (MC) are present in nearly all tissues in the body and participate in many physiological processes including allergy, tissue remodelling, fibrosis, angiogenesis, and autoimmunity. They can be activated by many stimuli, including allergic and innate immune stimulation. When activated,...
-
2010
Stothard, P., Dennis, J.J., Lynch, K.H.
Abstract Background: The Burkholderia cepacia complex (BCC) is comprised of at least seventeen Gram-negative species that cause infections in cystic fibrosis patients. Because BCC bacteria are broadly antibiotic resistant, phage therapy is currently being investigated as a possible alternative...
-
Spring 2011
Nitric oxide (NO) is a short-lived free radical that plays a critical role in the regulation of cellular signalling. Mast cell (MC) derived NO and exogenous NO regulate MC activities including the inhibition of MC degranulation. At a molecular level the intermediate metabolites of NO modify...
-
Fall 2016
Introduction: Hypertrophic scar (HTS) formation is a fibroproliferative disorder that commonly follows deep dermal burns with prolonged inflammation. It is characterized by excessive extracellular matrix such as collagen deposition mainly by dermal fibroblasts. Mast cells have been implicated in...
-
Fall 2018
Mast cells (MCs) are tissue resident innate immune cells. They are recognized for their immunoregulatory roles in the regulation of innate and adaptive immunity. Aberrant activation and responses of MCs result in inflammatory disorders like allergies. Thus, the biological pathways that control MC...
-
Fall 2019
Background: Dermal fibroproliferative disorders are forms of aberrant cutaneous wound healing, which can lead to the formation of hypertrophic scars (HTS). HTS develop after prolonged healing of deep dermal burns and are associated with excessive inflammation. HTS are characterized by exaggerated...