Search
Skip to Search Results- 6Agricultural, Food and Nutritional Science, Department of
- 6Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 3Biochemistry, Department of
- 3Biochemistry, Department of/Journal Articles (Biochemistry)
- 3Graduate and Postdoctoral Studies (GPS), Faculty of
- 3Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
-
A novel human mutation in the SLC9A1 gene results in abolition of na+/H+ exchanger activity
Download2015-01-01
The SLC9A1 gene, the Na+/H+ exchanger isoform 1 is the principal plasma membrane Na+/H+ exchanger of mammalian cells and functions by exchanging one intracellular proton for one extracellular sodium. The human protein is 815 amino acids in length. Five hundred N-terminal amino acids make up the...
-
Altered microRNA expression in bovine subcutaneous and visceral adipose tissues from cattle under different diet
Download2012
Guan, Leluo, Romao, Josue M., McAllister, Tim, He, Maolong, Jin, Weiwu
Background MicroRNAs (miRNAs) are a class of molecular regulators found to participate in numerous biological processes, including adipogenesis in mammals. This study aimed to evaluate the differences of miRNA expression between bovine subcutaneous (backfat) and visceral fat depots (perirenal...
-
Elucidation of molecular mechanisms of physiological variations between bovine subcutaneous and visceral fat depots under different nutritional regimes
Download2013
Jin, Weiwu, He, Maolong, Guan, Leluo, Romao, Josue M., McAllister, Tim
Adipose tissue plays a critical role in energy homeostasis and metabolism. There is sparse understanding of the molecular regulation at the protein level of bovine adipose tissues, especially within different fat depots under different nutritional regimes. The objective of this study was to...
-
Exploring the Role of ADAM17 in Vascular Smooth Muscle Cells and Macrophages Within the Atherosclerotic Plaque
DownloadSpring 2024
Atherosclerosis, characterized by arterial fat deposits, is the root cause of many cardiovascular diseases. Plaque deposition results from a series of events initiated by elevated plasma cholesterol, inflammation of the arterial wall, cholesterol uptake, macrophage-derived foam cell formation,...
-
Huh7.5 Cells Grown in Human Serum as a Model to Study the Effects of Hepatitis C Virus Infection on Lipid Catabolism
DownloadSpring 2018
Our goal is to study the additional elements of the mechanism of steatosis underlying hepatitis C virus (HCV) infection. Human hepatoma Huh7.5 cells cultured in human serum (HS) were used as a model to study the development of steatosis. Huh7.5 cells grown in HS media were chosen to study the...
-
Identification of a pair of phospholipid:diacylglycerol acyltransferases from developing flax (Linum usitatissiumum L.) seed catalyzing the selective production of trilinolenin
Download2013
Wickramarathna, Aruna D., Siloto, Rodrigo M. P., Mietkiewska, Elzbieta, Pan, Xue, Weselake, Randall J.
The oil from flax (Linum usitatissimum L.) has high amounts of α-linolenic acid (ALA; 18:3cisΔ9,12,15) and is one of the richest sources of omega-3 polyunsaturated fatty acids (ω-3-PUFAs). To produce ∼57% ALA in triacylglycerol (TAG), it is likely that flax contains enzymes that can efficiently...
-
2012
Wan, Zhongxiao, MacDonald, Tara, Wright, David C., Holloway, Graham P., Chan, Catherine B., Perry, Christopher G.
Background Adipose tissue mitochondria have been implicated as key mediators of systemic metabolism. We have shown that IL-6 activates AMPK, a mediator of mitochondrial biogenesis, in adipose tissue; however, IL-6−/− mice fed a high fat diet have been reported to develop insulin resistance. These...
-
Na+/H+ exchanger isoform 1-induced osteopontin expression facilitates cardiomyocyte hypertrophy
Download2015-01-01
Mohamed, Iman A., Gadeau, Alain-Pierre, Fliegel, Larry, Lopaschuk, Gary, Mlih, Mohamed, Abdulrahman, Nabeel, Filmore, Natasha, Mraiche, Fatima
Enhanced expression and activity of the Na+/H+ exchanger isoform 1 (NHE1) has been implicated in cardiomyocyte hypertrophy in various experimental models. The upregulation of NHE1 was correlated with an increase in osteopontin (OPN) expression in models of cardiac hypertrophy (CH), and the...
-
Plant acyl-CoA:lysophosphatidylcholine acyltransferases (LPCATs) have different specificities in their forward and reverse reactions
Download2013
Heinz, Ernst, Zhou, Xue-Rong, Banas, Antoni, Green, Allan, Jasieniecka, Katarzyna, Weselake, Randall, Smith, Mark A., Stymne, Sten, Bayon, Shen, Zou, Jitao, Lager, Ida, Dyer, John M., Shockey, Jay M., Yilmaz, Jenny L., Wang, Peng, Kazachkov, Michael
Acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT) enzymes have central roles in acyl editing of phosphatidylcholine (PC). Plant LPCAT genes were expressed in yeast and characterized biochemically in microsomal preparations of the cells. Specificities for different acyl-CoAs were similar...
-
Stop codon polymorphisms in the human SLC9A1 gene disrupt or compromise na+/H+ exchanger function
Download2016-01-01
Li, Xiuju J., Augustine, Aruna, Chen, Shuo, Fliegel, Larry
The NHE1 isoform of the mammalian Na+/H+ exchanger is a ubiquitous plasma membrane protein that regulates intracellular pH in mammalian cells by removing one intracellular proton in exchange for one extracellular sodium. Deletion of the NHE1 gene (SLC9A1) affects the growth and motor ability of...