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Skip to Search Results- 1Abdussalam, Ali MA
- 1Abu Alrub, Osama Y
- 1Aburasayn, Hanin
- 1Achtymichuk, Karly A
- 1Afhami, Shima
- 1Ata, Nicole
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Fall 2015
Phosphatidylethanolamine N-methyltransferase (PEMT), a liver enriched enzyme, is responsible for approximately one third of hepatic phosphatidylcholine (PC) biosynthesis via three sequential methylations of phosphatidylethanolamine (PE). PEMT is also expressed in white adipose tissue (WAT). When...
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Spring 2014
The effects of food messaging in video games remain unexplored despite the popularity of the medium among adolescents and the growing potential for food messaging in video games. My three research objects were to: (1) identify how healthy and unhealthy foods are depicted in video games; (2)...
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Fall 2016
Adults with class II/III obesity (BMI ≥35 kg/m2) are at increased health risk, and may also present with lower lean mass in relation to excess adiposity, a condition termed sarcopenic obesity. A variety of body composition indices and cutpoints have been used to define this condition, mostly in...
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Profiling the Bacterial and Fungal Gut Microbiome of Children with and without Prader-Willi Syndrome (PWS)
DownloadFall 2020
Obesity is a complex multifactorial disease that has a large array of direct (e.g. altered metabolic and inflammatory profile) and indirect (e.g. mental health concerns etc.) consequences on health and is associated with increased morbidity and mortality. Prader-Willi Syndrome (PWS) is the most...
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Fall 2014
Cardiac Fatty acids β-oxidation (FAO) markedly increases during maturation and become the major source of energy for the adult heart. However, excessive rates of FAO can compromise cardiac function in obesity, diabetes, and heart failure. Lysine acetylation has recently been identified as a...
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The Effects of Elements of Cardiometabolic Syndrome on Metformin Disposition: Obesity and Hyperlipidemia
DownloadFall 2015
The influences of obesity, Roux-en-Y gastric bypass bariatric (RYGB) surgery and hyperlipidemia on metformin pharmacokinetics (PK) were investigated. A sensitive and novel HPLC-UV reverse phase assay method was developed and utilized. Detection and mass characterization for metformin metabolites...
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Fall 2019
Background: Functional mobility is an important factor associated with quality of life. However, it is often compromised in individuals with obesity due to changes in body function and structures. With excessive adipose tissue accumulation, some individuals have a shifted center of mass,...
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Spring 2016
The prevalence of obesity worldwide has increased in the last few decades. The risk of obesity comes from its association with various clinical diseases especially cardiovascular diseases and diabetes. In this thesis, we assessed the expression of some drug metabolizing enzymes and transport...
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The Impact of Restrictive Drug Coverage Policies on Pharmacoepidemiologic Methods and Health Outcomes
DownloadSpring 2012
The unintended consequences of restrictive drug coverage policies on epidemiologic research methods and population health outcomes have been understudied. The primary objective of this program of research was to study the impact of these policies on the magnitude and direction of potential bias...