Search
Skip to Search Results- 2AlZahal, Ousama
- 2Bao, H.
- 2Basu, Urmila
- 2Chan, Catherine B.
- 2Dionissopoulos, Louis
- 2Dixon, Walter T.
- 27Graduate and Postdoctoral Studies (GPS), Faculty of
- 27Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 12Agricultural, Food and Nutritional Science, Department of
- 12Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 12Biological Sciences, Department of
- 12Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 9Department of Agricultural, Food, and Nutritional Science
- 4Department of Biological Sciences
- 2Department of Computing Science
- 2Department of Medicine
- 2Medical Sciences-Laboratory Medicine and Pathology
- 1Department of Cell Biology
- 2Damaraju, Sambasivarao (Laboratory Medicine and Pathology)
- 1Baracos, Vickie (Oncology)
- 1Belosevic, Miodrag (Biological Sciences)
- 1Dinu, Irina (Department of Public Health Sciences)
- 1Dixon, Walter (Agricultural, Food, and Nutritional Science)
- 1Doug Wiens (Mathematical and Statistical Sciences)
-
Identifying Gene Expression Differences Induced by Diets that Lead to Higher Omega-3 Fatty-Acid Deposition in Beef Cows
DownloadFall 2015
A strong emphasis on the type of fatty acids (FAs) consumed in the human diet has emerged in recent years. In this context, the various health benefits of consuming omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have been widely reported. Supplementation of beef cattle diets with flaxseed, a...
-
IL-6 indirectly modulates the induction of glyceroneogenic enzmes in adipose tissue during exercise
Download2012
Wan, Zhongxiao, Beaudoin, Marie-Soleil, Castellani, Laura, Wright, David C., Ritchie, Ian, Chan, Catherine B.
Background Glyceroneogenesis is an important step in the control of fatty acid re-esterification with PEPCK and PDK4 being identified as key enzymes in this process. We have previously shown that glyceroneogenic enzymes such as PDK4 are rapidly induced in white adipose tissue during exercise....
-
2012
Wan, Zhongxiao, MacDonald, Tara, Wright, David C., Holloway, Graham P., Chan, Catherine B., Perry, Christopher G.
Background Adipose tissue mitochondria have been implicated as key mediators of systemic metabolism. We have shown that IL-6 activates AMPK, a mediator of mitochondrial biogenesis, in adipose tissue; however, IL-6−/− mice fed a high fat diet have been reported to develop insulin resistance. These...
-
Fall 2009
Pig follicle development is a complex but poorly understood process involving both gonadotrophins and local ovarian factors. A series of studies sought to investigate these intrafollicular cell-to-cell interactions. Microarray analysis combined with gene ontology revealed that the oocyte,...
-
Looking beyond the standard genome-wide association study: Biologically-motivated methodological approaches to discover novel genetic variants associated with complex human traits and disease
DownloadFall 2018
The standard approach for testing associations between common single nucleotide genetic variants (referred to as single nucleotide polymorphisms or SNPs) and disease entails testing disease associations for each SNP in the genome individually. This “hypothesis-free” approach has identified...
-
Maternal and Paternal Genomes Differentially Affect Myofibre Characteristics and Muscle Weights of Bovine Fetuses at Midgestation
Download2013
Kruk, Z. A., Xiang R., Rutley, D. L., Thomsen, D. A., Anderson, G. I., Fitzsimmons, C., Ghanipoor-Samami, M., Hiendleder, S., Roberts, C. T., Eindorf, T., Burns, B. M., Greenwood, P. L., Johns, W. H.
Postnatal myofibre characteristics and muscle mass are largely determined during fetal development and may be significantly affected by epigenetic parent-of-origin effects. However, data on such effects in prenatal muscle development that could help understand unexplained variation in postnatal...
-
MicroRNA Buffering and Altered Variance of Gene Expression in Response to Salmonella Infection
Download2014
Plastow, G. S., Bao, H., Kommadath, A., Guan, L. L., Tuggle, C. K., Stothard, P.
One potential role of miRNAs is to buffer variation in gene expression, although conflicting results have been reported. To investigate the buffering role of miRNAs in response to Salmonella infection in pigs, we sequenced miRNA and mRNA in whole blood from 15 pig samples before and after...
-
Spring 2013
If all cells in a multicellular organism contain exactly the same genetic information, the question arises of how tissue types with distinct gene expression profiles are formed and maintained over the life of the organism. These different temporal and spatial gene expression patterns are thought...
-
Molecular cloning, pharmacological characterization and brain mapping of the melanocortin 4 receptor in the goldfish: Involvement in the control of food intake
Download2003
Schioth, H.B., Cerdá-Reverter, J.M., Peter, R.E., Ringholm, A.
We report cloning, pharmacological characterization, tissue distribution, detailed brain mapping, and role in control of food intake of melanocortin 4 receptor in goldfish (gMC4R). The gMC4R protein has 68% identity with the human ortholog and is conserved in important functional domains....
-
Fall 2015
Malignant glioma (MG), comprised of grade III (anaplastic astrocytoma) and grade IV (glioblastoma) astrocytoma, is the most common adult brain tumour, with an incidence of ~4 in 100 000 people. Despite aggressive treatment with surgery, radiation, and chemotherapy, survival remains dismal, with...