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Skip to Search Results- 3Boyd, T. J. M.
- 2Barr, H. C.
- 2Rankin, Robert
- 1Abdul Rahman, Siti Aishah
- 1Ahrari, Malema
- 1Alles, Sascha R
- 38Graduate and Postdoctoral Studies (GPS), Faculty of
- 38Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 3Physics, Department of
- 3Physics, Department of/Journal Articles (Physics)
- 1Biological Sciences, Department of
- 1Biological Sciences, Department of/Journal Articles (Biological Sciences)
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Spring 2016
This thesis examines the cellular basis of the acute (<1 hour) anti-allodynic actions of the clinically-approved neuropathic pain drug gabapentin (GBP) in rats at the level of the spinal dorsal horn and primary somatosensory cortex. Although the clinical effectiveness of the alpha-2-delta (α2δ)...
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Fall 2022
The reason and functional relevance of why we sleep continues to perplex researchers. One fundamental reason behind why sleep remains a mystery is because it is challenging to study given how easily it is disrupted. Anesthesia has been suggested to be a model for studying sleep given the...
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Antagonistic modulation of spontaneous neural network activities in isolated newborn rat brainstem preparations by opioids and methylxanthines
DownloadFall 2012
Apnea of prematurity is a common problem among the infants born before term pregnancy. Administration of respiratory stimulating drugs methylxanthines is the most frequent therapy, often in combination with the use of intubation. Opioids are used to reduce the pain associated with intubation,...
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Application of genomics-based tools leading to the identification of markers on bovine chromosome 14 influencing milk production and carcass quality traits
DownloadFall 2009
Genetic improvements in beef and dairy cattle can bring significant advances in satisfying the global food demand, which is expected to double by 2050. Several DNA markers have been identified on bovine chromosome 14 (BTA14), but low mapping resolution prevents their refinement for identification...
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Fall 2012
ATP actions on central inspiratory networks are determined by a three-part signaling system comprising: i) excitatory actions of ATP at P2 receptors (Rs) ii) ectonucleotidases that degrade ATP into adenosine (ADO), and iii) inhibitory actions of ADO at P1Rs. During hypoxia, an initial increase in...
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Characteristics of Patients Reviewed by a Nurse Practitioner within an Outpatient Palliative Radiation Oncology Clinic
DownloadFall 2017
Cancer is a highly prevalent illness in Canada, with half of Canadians developing cancer and one quarter dying of the disease. In spite of significant advancements in cancer diagnosis and treatments, many cancers still have a poor prognosis. Palliative radiotherapy (PRT) is a common and effective...
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Combination Radiation Therapy and Oncolytic Vaccinia Virus Therapy in Preclinical Models of Glioma
DownloadSpring 2017
Gliomas are the most common primary malignant brain tumour in adults, with glioblastoma multiforme (GBM), the most common and most deadly form of glioma, making up over half of all diagnosed cancers in the brain/central nervous system. The standard of care for gliomas has remained unchanged for...
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2019-01-01
Nair, Sindhu G., Loppnow, Glen R.
It has been well established that mutations in K-Ras and N-Ras proto-oncogenes can convert them into active oncogenes. Current molecular cancer research has been focused on determining the key steps by which cellular genes become oncogenes and not on the underlying and fundamental chemical damage...
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Fall 2012
To understand the water cycle on Mars, details of mass and energy transfer between the surface and the atmosphere are of importance. A complete model, involving transient variations of the water in gaseous and solid phases in the atmosphere and the regolith, is developed and solved numerically...