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Skip to Search Results- 7Islet transplantation
- 3Neonatal porcine islets
- 2Diabetes
- 2Mesenchymal stem cells
- 2Xenotransplantation
- 1Biomaterials
- 1Abualhassan, Nasser
- 1Akbari Motlagh, Roozbeh
- 1Arefanian, Hossein
- 1Ellis, Cara E
- 1Hayward, Julie A
- 1McCall, Michael David
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Tolerance to neonatal porcine islet xenografts induced by a combination of monoclonal antibodies
DownloadFall 2009
Islet transplantation is a more physiological way to treat type 1 diabetes. However, shortage of donor tissue and chronic administration of immune suppressive drugs has limited the widespread application of this therapy for all patients with type 1 diabetes, particularly children suffering from...
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Fall 2011
Islet transplantation is promising treatment for certain patients with type 1 diabetes who experience recurrent episodes of hypoglycemia with unawareness. One opportunity to improve on islet transplant outcomes and potentially broaden the recipient population, is to reduce the early post...
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Spring 2013
Type 1 diabetes mellitus (T1DM) is a chronic disorder of glucose metabolism due to autoimmune destruction of insulin producing β-cells. Although insulin therapy is the standard treatment for T1DM, islet transplantation, which has emerged as an alternative to insulin injection, offers a more...
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Fall 2015
The development of the Edmonton protocol was an important milestone in the process of establishing islet transplantation as a cure for diabetes. However, many challenges must still be overcome, including the shortage of donor organs. To address this issue, we believe that neonatal porcine islets...
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Improving Techniques for Cell Implantation and their Impact on Managing Diseases of the Pancreas
DownloadFall 2016
The use of experimental animals early in the twentieth century has revolutionized medicine and significantly improved our understanding of disease processes. The ability to reproduce a medical condition in a mouse model has provided great insights into the cellular and molecular biology of the...
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Fall 2017
Mesenchymal stem cells (MSCs) have immuno-regulatory, anti-inflammatory, and pro-angiogenic properties through the secretion of a myriad of trophic factors, and have been shown to have a beneficial effect on graft function. In this thesis we investigated whether MSCs’ have an effect on neonatal...
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Fall 2023
Islet transplantation can achieve insulin independence in individuals with type 1 diabetes. However, islets derived from multiple donors are often required, and functional β-cells are lost early after transplantation. Notably, up to 80% of newly transplanted islets are lost due to cell death...