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Skip to Search Results- 1Barakat, Khaled H.
- 1Dronyk, Ashley D
- 1Freschauf, Gary
- 1Gentile, Francesco
- 1Jiang, Bingcheng
- 1Khairy, Mostafa
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Spring 2015
Besides being the most popular drug in the world, caffeine is an attractive tool used in research to help us answer fascinating scientific questions, because caffeine impinges on a number of molecular pathways. In my research, I used caffeine to study DNA repair pathways and insect xenobiotic...
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Computational High Throughput Screening Targeting DNA Repair Proteins To Improve Cancer Therapy
DownloadSpring 2012
Developing a new drug is a complex, highly structured, and expensive task. The further a potential drug progresses in the development process, the more costly its failure becomes. Virtual screening (VS) is the initial stage of a drug discovery process. Its job is to screen large compound...
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Spring 2019
Computational methods are nowadays essential tools employed in the field of drug design. Indeed, bringing a molecular compound from bench to clinic is a challenging, time-consuming and expensive goal to achieve. Computer-aided drug design (CADD) techniques aim to simplify this process, by...
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Evaluating the consequences of polynucleotide kinase/phosphatase (PNKP) mutations in neurological diseases
DownloadSpring 2022
Genomic stability is extremely important for developing or maintaining normal neurological functions, as the nervous system is constantly suffering from endogenous DNA damage. To maintain such stability, living cells are protected by several different DNA repair pathways. Polynucleotide...
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Fall 2013
Breast cancer is the most common cancer among women in the developed world. The disease results from the combined effects of genetic, environmental, reproductive and lifestyle risk factors. Germline DNA variations identified thus far by linkage and genome-wide association studies (GWASs) account...
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Identification of small molecule inhibitors of the human DNA repair enzyme polynucleotide kinase/phosphatase
DownloadFall 2011
Human polynucleotide kinase/phosphatase (hPNKP) is a bifunctional DNA repair enzyme that phosphorylates DNA 5’-termini and dephosphorylates DNA 3’-termini. hPNKP has been shown to be involved in both single- and double-strand break repair, and cancer cells depleted of hPNKP show significant...
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Fall 2011
Topoisomerase II-beta binding protein 1 (TopBP1) is a critical regulatory protein that integrates diverse signals in the DNA damage response. In response to DNA replication stress, TopBP1 participates in a series of protein interactions to collectively activate the key Ser/Thr kinase, Ataxia...
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Spring 2011
Radiation therapy targets cancer cell death by overwhelming cells with harmful DNA damage. Understanding how cells repair radiation damage and in particular how they become resistant to radiation therapy is important for effective cancer treatment. Our lab made the novel discovery that Bcl10, a...
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Novel Therapeutic Approaches for Cancer Therapy Based on Targeting the Human DNA Repair Enzyme Polynucleotide Kinase/Phosphatase
DownloadFall 2018
The relentless growth of tumors is triggered by a complex array of molecular changes such as DNA damage, disruption of cell-cycle progression, uncontrolled proliferation and escaping cell death. Various therapies have been developed to treat cancer, many of which kill cancer cells by damaging...
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Fall 2022
Glioblastoma has a devastating prognosis, and a remarkably low survival rate. Current therapeutic strategies including surgery, radiation and temozolomide are only useful as a palliative therapy, with no significant increase in overall survival. In this study, we investigated multiple therapeutic...