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Skip to Search Results- 4Gänzle, Michael G.
- 3Finlay, B. Brett
- 3Willing, Benjamin P.
- 2Antunes, L. Caetano M.
- 2Dieleman, Levinus A.
- 2Farhangfar, Arazm
- 31Graduate and Postdoctoral Studies (GPS), Faculty of
- 31Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 10Agricultural, Food and Nutritional Science, Department of
- 10Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 2Agricultural, Life, and Environmental Sciences, Faculty of
- 2Agricultural, Life, and Environmental Sciences, Faculty of/Journal Articles (Agricultural, Life, & Environmental Sciences)
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Lipid Modified Polymers for Transfection of Human CRL Fibroblasts, and for siRNA Mediated MDR Reversal in Melanoma Cancer Therapy
DownloadFall 2010
Gene delivery for therapeutic purposes is quickly emerging as the best potential treatment option for inherited genetic diseases and cancer. Viral gene carriers have been the choice for this purpose due to their high efficiency, but harmful immunogenic and oncogenic host reactions have limited...
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Fall 2010
Escalating cancer rates and an increase in the complexity and duration of chemotherapy regimens have brought the issue of cancer treatment at home to the forefront. For the participants of this study, home chemotherapy was offered as a potential treatment choice. Ten patients who accepted were...
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The intestinal microbiota plays a role in Salmonella-induced colitis independent of pathogen colonization
Download2011
Antunes, L. Caetano M., Gill, Navkiran, Russell, Shannon L., Finlay, B. Brett, Ferreira, Rosana B., Croxen, Matthew A., Willing, Benjamin P.
The intestinal microbiota is composed of hundreds of species of bacteria, fungi and protozoa and is critical for numerous biological processes, such as nutrient acquisition, vitamin production, and colonization resistance against bacterial pathogens. We studied the role of the intestinal...
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2011
Willing, Benjamin P., Finlay, B. Brett , Thanachayanont, Teerawat, Croxen, Matthew, Vacharaksa, Anjalee
Host resistance to bacterial infections is thought to be dictated by host genetic factors. Infections by the natural murine enteric pathogen Citrobacter rodentium (used as a model of human enteropathogenic and enterohaemorrhagic E. coli infections) vary between mice strains, from mild...
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Diet and environment shape fecal bacterial microbiota composition and enteric pathogen load of grizzly bears
Download2011-01-01
Northrup, Joseph M., Cristescu, Bogdan, Schwab, Clarissa, Stenhouse, Gordon B., Gänzle, Michael G.
Background Diet and environment impact the composition of mammalian intestinal microbiota; dietary or health disturbances trigger alterations in intestinal microbiota composition and render the host susceptible to enteric pathogens. To date no long term monitoring data exist on the fecal...
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Fall 2011
This study determined how chemotherapy treatment for colorectal cancer alters hepatic fat metabolism. Livers were isolated from tumor-bearing animals after one and two cycles of chemotherapy consisting of irinotecan plus 5-fluorouracil. Fatty acid amounts and composition within triglycerides (TG)...
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2012
Ketabi, Ali, Baracos, Vickie E., Field, Catherine J., Lin, Xiaoxi, Xue, Hongyu, Bibova, Ilona, Gänzle, Michael G., Dieleman, Levinus A., Sawyer, Michael B.
Intestinal microbiota mediate toxicity of irinotecan (CPT-11) cancer therapies and cause systemic infection after CPT-11-induced loss of barrier function. The intestinal microbiota and their functions are thus potential targets for treatment to mitigate CPT-11 toxicity. However, microbiota...
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Neutrophil elastase alters the murine gut mirobiota resulting in enhanced Salmonella colonization
Download2012
Hartmann, Martin, Sekirov, Inna, Finlay, B. Brett, Al-Zahrani, Fatimah, Willing, Benjamin P., Ferreira, Rosana B. R., Gill, Navkiran, Antunes, L. Caetano M.
The intestinal microbiota has been found to play a central role in the colonization of Salmonella enterica serovar Typhimurium in the gastrointestinal tract. In this study, we present a novel process through which Salmonella benefit from inflammatory induced changes in the microbiota in order to...
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Lactobacillus reuteri maintains a functional mucosal barrier during DSS treatment despite mucus layer dysfunction
Download2012
Rang, Sara, Roos, Stefan, Phillipson, Mia, Holm, Lena, Dicksved, Johan, Willing, Ben P., Petersson, Joel, Schreiber, Olof
Treatment with the probiotic bacterium Lactobacillus reuteri has been shown to prevent dextran sodium sulfate (DSS)-induced colitis in rats. This is partly due to reduced P-selectin-dependent leukocyte- and platelet-endothelial cell interactions, however, the mechanism behind this protective...