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2010

Clawson,M. L., Wang, Z., Stothard, P., McKay, S., Laegreid, W. W., Williams J. L., Murdoch, B. M., Settles, M., Moore, S. S., Prasad, A.

Background Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk. Polymorphisms that alter the prion protein of sheep or humans have been associated with variations in...

2007

Stothard, P., Wang, Z., de Givry, S., Marques, E., Moore, S. S., Womack, J., Murdoch, B.

Background Radiation hybrid (RH) maps are considered to be a tool of choice for fine mapping closely linked loci, considering that the resolution of linkage maps is determined by the number of informative meiosis and recombination events which may require very large mapping populations....

2008

Schnabel, R. D., Wang, Z., Taylor, J. F., Gill, C. A., Van Tassell, C. P., Gao, C., Aerts, J., Williams, J. L., Neto, E. D., Murdoch, B. M., Matukumalli, L. K., Coppieters, W., McKay, S. D., Mannenl, H., Crews, D., Moore, S. S.

Background Analyses of population structure and breed diversity have provided insight into the origin and evolution of cattle. Previously, these studies have used a low density of microsatellite markers, however, with the large number of single nucleotide polymorphism markers that are now...

2002

Fitzsimmons, C. J., Thue, T. D., Buchanan, F. C., Winkelman-Sim, D. C., Schmutz, S. M., Van Kessel, A. G.

Previously, we have shown that alleles of the BM1500 microsatellite, located 3.6 kb downstream of the leptin gene in cattle, were associated with carcass fat measures in a population of 154 unrelated beef bulls. Subsequently, a cytosine (C) to thymine (T) transition that encoded an amino acid...

2008

Kolbehdari, D., Stothard, P., Schnabel, R., Wang, Z., Marques, E., Taylor, J. F., Moore, S. S.

Background Linkage disequilibrium (LD) maps can provide a wealth of information on specific marker-phenotype relationships, especially in areas of the genome where positional candidate genes with similar functions are located. A recently published high resolution radiation hybrid map of bovine...

2007

Schnabel, R. D., Wang, Z., Mannenl, H., Gill, C. A., Van Tassell, C. P., Gao, C., Aerts, J., Williams, J. L., Neto, E. D., Moore, S. S., Matukumalli, L. K., Coppieters, W., McKay, S. D., Taylor, J. F., Crews, D., Murdoch, B. M.

Background Bovine whole genome linkage disequilibrium maps were constructed for eight breeds of cattle. These data provide fundamental information concerning bovine genome organization which will allow the design of studies to associate genetic variation with economically important traits and...