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Skip to Search Results- 5Gänzle, Michael G.
- 5Willing, Benjamin P.
- 4Finlay, B. Brett
- 2Antunes, L. Caetano M.
- 2Cristescu, Bogdan
- 2Croxen, Matthew A.
- 49Graduate and Postdoctoral Studies (GPS), Faculty of
- 49Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 20Agricultural, Food and Nutritional Science, Department of
- 20Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 3Biological Sciences, Department of
- 3Biological Sciences, Department of/Journal Articles (Biological Sciences)
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Mechanisms of Neonatal Intestinal Failure-Associated Liver Disease: Exploring the Gut-Liver Axis
DownloadSpring 2018
Neonates with intestinal failure (IF), who must rely on parenteral nutrition (PN) for growth and maintenance of health, are at risk for intestinal failure-associated liver disease (IFALD). In neonates, short bowel syndrome (SBS) as a result of intestinal resection is the most common cause of IF....
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Fall 2023
Background: Vitamin A status is an important health determinant. Deficiency of this micronutrient is a serious global health issue in the developing nations as the leading cause of preventable blindness in children and is a significant contributor to long-term morbidity and mortality. Nutritional...
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Na+/H+ exchange in the tumour microenvironment: Does NHE1 drive breast cancer carcinogenesis?
Download2015-01-01
Amith, Schammim Ray, Fong, Sunny, Baksh, Shairaz, Fliegel, Larry
Ionic messengers signal several critical events in carcinogenesis, including metastasis, the leading cause of patient mortality. The aberrant metabolic, proliferative and anti-apoptotic nature of neoplastic cells can be traced to the abnormal expression of their ion transporters and related...
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Nanodelivery of Novel Inhibitors of ERCC1/XPF for sensitizing colorectal cancer cell to platinum drugs
DownloadSpring 2023
This project's long-term goal is to increase the efficacy of genotoxic therapeutics through thesensitization of cells to DNA-damaging therapy ahead of the treatment. The focus of this projectwas on the enhancement of platinum-based chemotherapeutics in colorectal cancer usingcolorectal cancer...
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Neutrophil elastase alters the murine gut mirobiota resulting in enhanced Salmonella colonization
Download2012
Hartmann, Martin, Sekirov, Inna, Finlay, B. Brett, Al-Zahrani, Fatimah, Willing, Benjamin P., Ferreira, Rosana B. R., Gill, Navkiran, Antunes, L. Caetano M.
The intestinal microbiota has been found to play a central role in the colonization of Salmonella enterica serovar Typhimurium in the gastrointestinal tract. In this study, we present a novel process through which Salmonella benefit from inflammatory induced changes in the microbiota in order to...
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Non digestible carbohydrates in the diet determine toxicity of irinotecan (CPT-11)/5-fluorouracil in rats independently of β-glucuronidase activity in intestinal lumen
DownloadFall 2012
Aim of this study was to assess effects of non-digestible carbohydrates on the pathobiology of mucosal injury after chemotherapy. Rats bearing colon tumor (n=6/diet) were fed diets including 8% (w/w) as either cellulose, inulin, fructo-oligosaccharide (OligoF), 50:50 (w/w) inulin and oligoF...
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Non-digestible fibers and dietary interventions: alternative approaches for the treatment of inflammatory bowel disease
DownloadSpring 2014
Crohn’s disease (CD) and ulcerative colitis (UC), collectively called inflammatory bowel disease (IBD), are associated with chronic intestinal inflammation, affecting approximately 0.7 % of Canadians. Intestinal microbial dysbiosis have been related to IBD. Therapies that manipulate gut...
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Novel Treatments for Intestinal Failure Explored in Neonatal Piglets with Short Bowel Syndrome: Focusing on the Microbiome, Sepsis and Trophic Factors
DownloadSpring 2024
Short bowel syndrome (SBS) is the leading cause of intestinal failure (IF) in infants, and occurs when there is a significant loss of intestine due to acquired or congenital reasons, leading to infants being unable to absorb sufficient nutrients for survival and growth. SBS traditionally had a...
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2015
Bell, R.C., Mostyn, A., Astbury, S., Symonds, M.E.
Adequate adaptation of the gastrointestinal (GI) tract is important during pregnancy to ensure that the increased metabolic demands by the developing fetus are met. These include changes in surface area mediated by villus hypertrophy and enhanced functional capacity of individual nutrient...
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Patterns of muscle, bone and fat accretion in three biological types of feedlot bulls on three dietary energy levels
Download1985
Patterson, D. L., Price, M. A., Berg, R. T.
The data used in this study consisted of 119 075 complete lactation records accumulated by record of performance (ROP) from 1976 to 1981. Each individual record consisted of 7, 8 or 9 monthly test day milk weights and corresponding fat percentage. The data for each breed (Ayrshire, Guernsey,...