Search
Skip to Search Results- 2Guan, Leluo
- 2Jin, Weiwu
- 2Veldhoen, Richard
- 1Abbasi Dezfouli, Meysam
- 1Ambrose, Divakar J.
- 1Amith, Schammim Ray
- 16Graduate and Postdoctoral Studies (GPS), Faculty of
- 16Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 5Agricultural, Food and Nutritional Science, Department of
- 5Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Biochemistry, Department of
- 1Biochemistry, Department of/Journal Articles (Biochemistry)
- 3Department of Agricultural, Food, and Nutritional Science
- 3Department of Biochemistry
- 1Department of Biomedical Engineering
- 1Department of Cell Biology
- 1Department of Chemistry
- 1Department of Physics
- 2Goping, Ing Swie (Biochemistry, Oncology)
- 1Co-supervisor: Dr. Marc Mackenzie (Oncology)
- 1Damaraju, Sambasivarao (Medical Sciences - Laboratory Medicine and Pathology)
- 1Davidge, Sandra (Obstetrics/Gynecology and Physiology)
- 1Davis, Faith (School of Public Health)
- 1DeLorey, Darren Faculty of Kinesiology, Sport, and Recreation
-
A path towards better cancer drugs: Modeling interactions between antimitotic agents and tubulin
DownloadFall 2015
Antimitotic agents, a class of cancer chemotherapies, target the tubulin protein in microtubules to suppress microtubule dynamics and affect the segregation of chromosomes during cell division. A variety of antimitotic agents are known, which range in status from clinically-approved agents to...
-
Analytical considerations and biology of milk conjugated linoleic acid synthesis in the bovine
DownloadSpring 2010
Biosynthesis of milk conjugated linoleic acid (CLA), a component of milk fat with demonstrated health benefits, requires a dietary source of PUFA. Even with PUFA supplementation, milk CLA is highly variable. Therefore, this study was aimed at identifying factors responsible for the variations in...
-
Are Sex and Estrogen Modulators of Sympathetic Vascular Control in Resting and Contracting Skeletal Muscle?
DownloadSpring 2018
The purpose of this thesis was to investigate whether sex and estrogen modulate sympathetic neurovascular control in resting and contracting skeletal muscle. This thesis also investigated the hypothesis that the effects of sex and estrogen on neurovascular control would be mediated by the signal...
-
Fall 2012
Taxane chemotherapy is widely used in the treatment of breast cancer. Despite its widespread clinical use, the molecular mechanisms of paclitaxel induced apoptosis remain unclear. Our laboratory has identified an important role for the BH3-only protein, BAD, in the paclitaxel induced cell death...
-
Brain fatty acid-binding protein and ω-3/ω-6 fatty acids: Mechanistic insight into the poor prognosis of malignant glioma cell migration
Download2010
Godbout, Roseline, Mita, Raja, Field, Catherine J., Beaulieu, Michael J.
Malignant gliomas (MG) are highly infiltrative tumors that consistently recur despite aggressive treatment. Brain fatty acid-binding protein (FABP7), which binds docosahexaenoic acid (DHA) and arachidonic acid (AA), localizes to sites of tumor infiltration and is associated with a poor prognosis...
-
Fall 2015
There is a concern that brain tumours are underreported in the Alberta Cancer Registry (ACR), yet no studies have been performed to investigate this issue. This study addresses the concern of underreporting of brain tumours in the ACR by assessing case ascertainment of primary brain tumours cases...
-
Construction of bovine whole-genome radiation hybrid and linkage maps using high-throughput genotyping
Download2007
Williams, J. L., Moore, S. S., Wang, Z., McKay, S. D., Murdoch, B. M.
High-density whole-genome maps are essential for ordering genes or markers and aid in the assembly of genome sequence. To increase the density of markers on the bovine radiation hybrid map, and hence contribute to the assembly of the bovine genome sequence, an Illumina® BeadStation was used to...
-
Development of a porcine (Sus scofus) embryo-specific microarray: Annotation and validation
Download2012
Dobrinsky, John, Zhou, Chi, Pasternak, J. Alexander, Dyck, Michael K., Foxcroft, George R., Nieminen, Julie, Tsoi, Stephen, Rigault, Philippe, Sirard, Marc-André, Robert, Claude, Grant, Jason R.
Background The domestic pig is an important livestock species and there is strong interest in the factors that affect the development of viable embryos and offspring in this species. A limited understanding of the molecular mechanisms involved in early embryonic development has inhibited our...
-
Drug Resistance in Breast Cancer: Characterization of Rationally Designed Paclitaxel Analogs in Model Systems
DownloadFall 2013
Breast cancer is a leading cause of cancer related deaths among women in the developed world. Treatment options for breast cancer include taxanes, which mediate cytotoxic effects by inducing microtubule polymerization which impedes cell division. Taxane resistant breast cancer is a mounting...
-
Fall 2022
Contraction-mediated inhibition of sympathetic vasoconstriction (sympatholysis) is enhanced in female compared with male rats. Acute pharmacological blockade of nitric oxide (NO) production abolished the sex difference in sympatholysis, indicating that NO-mediated sympatholysis is elevated in...