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Skip to Search Results- 2Bone morphogenetic protein-2
- 2Drug delivery
- 1Antibacteria activity
- 1Bisphosphonate
- 1Bone
- 1Bone targeting
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Spring 2011
The objective of this thesis is to design nanoparticle (NP)-based drug delivery systems suitable for treatment of bone diseases. Two types of nanocarriers, (1) polymer coated bovine serum albumin (BSA) NPs and (2) lipid based NPs (micelles and liposomes) were investigated. The BSA NPs were...
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Effects of macrophages and noggin suppression on the BMP-2-induced osteogenesis of human bone marrow mesenchymal stem cells
DownloadSpring 2011
The osteogenic effects of bone morphogenetic protein-2 (BMP-2) on human mesenchymal stem cells (MSCs) are less profound than expected as compared with rodent cells, and supraphysiological dose of BMP-2 is required to achieve desired clinical outcome. The mechanism for this phenomenon is unclear....
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Sustained Drug Release And Antibacterial Activity Of Ampicillin incorporated Poly (methyl methacrylate)-Nylon6 Core/Shell Nanofibers
DownloadFall 2012
A drug delivery system was designed based on the encapsulation of Ampicillin sodium salt in Poly (methyl methacrylate)(PMMA)-Nylon6 core/shell nanofibers and the release characteristics and antibacterial activity of the system were investigated. It was revealed that the system is capable of...