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Skip to Search Results- 3Immunoassay
- 3Microfluidics
- 2Microchip
- 1Biomolecule Immobilization
- 1Colloidal Self Assembly (CSA)
- 1Covalent
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Development and Characterization of Interfacial Chemistry for Biomolecule Immobilization in Surface Plasmon Resonance (SPR) Imaging Studies
DownloadFall 2009
Surface immobilization of probe molecules in surface based assays is a key area of research in the continued development of immunoassay microarrays. Interest continues to grow in microarray based immunoassays given their potential as a high throughput technique for immunodiagnostics. Therefore,...
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Functionalized Bead Based Microchip for Immunoassay and Virus Immuno-affinity Chromatography
DownloadFall 2014
We demonstrate the functionalization of a highly ordered porous molecular sieving matrix created by colloidal self-assembly (CSA) of 2 micrometer diameter silica particles in microfluidic chips, for highly efficient immuno-capture of viruses. By tuning the particle size, with appropriate surface...
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Fall 2012
Gold nanoparticles (AuNPs) are at the forefront of many research areas and generally require very specific surface functionalities to be compatible with targeted applications. Suitable modification schemes should be simple, fast, and robust. A common surface modification involves the use of...
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Protein Separation with Self-Assembled Nanoparticle Beds: Mechanism and Separation Performance
DownloadSpring 2016
This thesis reports the separation behavior of SDS-protein complexes in colloidal self-assembled (CSA) nanoparticle beds, and the processes of stabilization of CSA beds for high voltage separation. First, the variation of electrophoretic mobility with molecular weight (6.5-66 kDa) of SDS-protein...
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Spring 2010
The research presented in this work explores the application of microfluidics to the field of proteomics through the design of a multi-channel microfluidic platform and the investigation of individual components of the system. The design of this microfluidic device allows the integration of...