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Computational identification of residues that modulate voltage sensitivity of voltage-gated potassium channels
Download2005
Background: Studies of the structure-function relationship in proteins for which no 3D structure is available are often based on inspection of multiple sequence alignments. Many functionally important residues of proteins can be identified because they are conserved during evolution. However,...
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2012-01-01
Poulin, R., Connors, B. M., Krkosek, M., Lewis, Mark A.
Allee effects are thought to mediate the dynamics of population colonization, particularly for invasive species. However, Allee effects acting on parasites have rarely been considered in the analogous process of infectious disease establishment and spread. We studied the colonization of...
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Empirical estimation of R0 for unknown transmission functions: The case of chronic wasting disease in Alberta
Download2015-01-01
Potapov, Alex, Merrill, Evelyn, Pybus, Margo, Lewis, Mark A.
We consider the problem of estimating the basic reproduction number R0 from data on prevalence dynamics at the beginning of a disease outbreak. We derive discrete and continuous time models, some coefficients of which are to be fitted from data. We show that prevalence of the disease is...
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2016-01-01
Potapov, Alex, Merrill, Evelyn, Pybus, Margo, Lewis, Mark A.
We develop a model of CWD management by nonselective deer harvest, currently the most feasible approach available for managing CWD in wild populations. We use the model to explore the effects of 6 common harvest strategies on disease prevalence and to identify potential optimal harvest policies...
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2021-01-01
Arezoo Haratian, Hadi Fazelinia, Zeinab Maleki, Pouria Ramazi, Hao Wang, Mark A. Lewis, Russell Greiner, David Wishart
This dataset provides information related to the outbreak of COVID-19 disease in the United States, including data from each of 3142 US counties from the beginning of the outbreak (January 2020) until June 2021. This data is collected from many public online databases and includes the...