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Subject: Brain fatty acid-binding protein Subject: Calcineurin Subject: BFABP Subject: Brain tumour Departments: Department of Oncology

  • Mechanistic Insight Into the Role of FABP7 in Malignant Glioma

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    Fall 2012

    Beaulieu, Michael J.

    Malignant gliomas (MG) are the most common and aggressive brain cancers. FABP7 is an intracellular lipid trafficking molecule whose expression correlates with reduced MG patient survival. FABP7 has been shown to increase the migratory behaviour of MG cells. Moreover, the migratory behaviour of...

  • Nuclear Factor I and Calpain Signaling in Glioblastoma

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    Fall 2019

    Vo, Minh The

    Glioblastoma (GBM), classified as WHO grade IV astrocytoma, is the most common and lethal adult primary brain tumour. Despite recent advances in treatment, GBM prognosis remains largely unchanged with most patients succumbing to the disease within ~15 months of diagnosis. This dismal outcome can...

  • Nuclear Factor I in Malignant Glioma

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    Fall 2015

    Brun, Miranda

    Malignant glioma (MG), comprised of grade III (anaplastic astrocytoma) and grade IV (glioblastoma) astrocytoma, is the most common adult brain tumour, with an incidence of ~4 in 100 000 people. Despite aggressive treatment with surgery, radiation, and chemotherapy, survival remains dismal, with...

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