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Skip to Search Results- 1Augustine, Aruna M
- 1Diakur, James Michael.
- 1Endean, Riley Thomas
- 1Gaetano, Cristoforo Giuseppe
- 1Keuling, Angela
- 1Mashhouri, Siavash
- 2Department of Biochemistry
- 2Department of Chemistry
- 1Department of Mathematical and Statistical Sciences
- 1Faculty of Pharmacy and Pharmaceutical Sciences
- 1Medical Sciences - Medical Genetics
- 1Medical Sciences-Oral Biology
- 1Andrew, Susan (Medical Genetics)
- 1Bergens, Steven (Chemistry)
- 1Dr. Brindley, David N. (Biochemisty)
- 1Dr. Shokrollah Elahi (Department of Dentistry, Department of Oncology, Department of Medical Microbiology and Immunology)
- 1Fliegel, Larry (Biochemistry)
- 1Franczak, Brian (MacEwan University, Mathematics and Statistics)
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Fall 2011
In the Introduction of this thesis, consideration is given to historical and ongoing value of investing research efforts in the total synthesis of natural products. Following this discussion is an explanation of the factors that guided the selection of palmerolide A as a synthetic target. The...
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Spring 2021
A thorough overview of esters and their reductions is presented. A large focus was placed on reductions via homogeneous catalytic hydrogenation. Although several ester hydrogenation systems have been developed, the production of highly enantioenriched alcohols has generally relied upon the usage...
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Characterization of the response of melanoma cell lines to inhibition of anti-apoptotic Bcl-2 proteins
DownloadSpring 2010
Malignant melanoma is resistant to almost all conventional forms of chemotherapy. Recent evidence suggests that anti-apoptotic proteins of the Bcl-2 family are overexpressed in melanoma and may contribute to melanoma’s striking resistance to apoptosis. ABT-737, a small-molecule inhibitor of...
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Parsimonious Contaminated Shifted Asymmetric Laplace Mixtures: Unsupervised Learning with Outlier Identification for Asymmetric Clusters in High Dimensions
DownloadFall 2021
A family of parsimonious contaminated shifted asymmetric Laplace mixtures is developed for asymmetric clusters in the presence of outliers and noise (referred to as bad points herein). A series of constraints are applied to a modified factor analyzer structure of the scale matrix parameters,...
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Fall 2017
Mammalian Na+/H+ Exchanger 1 is a ubiquitously expressed membrane protein, which is dedicated to maintaining the acid-base balance in the cell. This balance is brought about by the exchange of one intracellular proton in exchange for extracellular sodium ion. NHE1 is the predominant isoform found...
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Fall 2012
Melanoma has the most rapidly rising incidence of all cancers and once metastasized it is very difficult to treat. This makes the identification of molecular pathways that are deregulated in melanoma a novel area of study. β-catenin (β-cat) is a multifunctional protein of the Wnt signaling...
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The curdlan and/or anti-VISTA monoclonal antibody enhances innate and adaptive immune responses in the mouse model of melanoma
DownloadSpring 2022
During the past decade, the field of immuno-oncology has been revolutionized by the emergence of immune checkpoint inhibitors (ICIs). However, acquired resistance to ICIs and relapse after immunotherapy are associated with defects in antigen presentation and the upregulation of exhaustion ligands...