Search
Skip to Search Results- 4Klassen, John S.
- 4Liu, Lan
- 4Lowary, Todd L.
- 4Wu, Jianping
- 3Chakrabarti, Subhadeep
- 3Majumder, Kaustav
- 59Graduate and Postdoctoral Studies (GPS), Faculty of
- 59Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 12Agricultural, Food and Nutritional Science, Department of
- 12Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 4Chemistry, Department of
- 4Chemistry, Department of/Journal Articles (Chemistry)
-
Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers
Download2014
Ueda, Keitaro, Ito, Kazuhiro, Kimura, Genki, Moses, Audric, Xiong, Yeping, Kizawa, Yasuo, Curtis, Jonathan M., Barnes, Peter J., Mercado, Nicolas
Anti-oxidant capacity is crucial defence against environmental or endogenous oxidative stress. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that plays a key defensive role against oxidative and cytotoxic stress and cellular senescence. However, Nrf2...
-
Spring 2014
Alzheimer’s disease (AD) is the most common form of dementia in the elderly. The major pathological features of AD are extracellular amyloid plaques, intracellular neurofibrillary tangles and neuronal loss. Amyloid beta (Aβ) peptide, the main component of the amyloid plaques, has been proposed to...
-
Anesthesia and the Aging Vasculature: Effects of Propofol on Hemodynamics and Vascular Function
DownloadSpring 2014
An increasing life expectancy in Canada has resulted in increasing proportions of elderly patients requiring anesthetic care for surgical procedures. Aging is associated with cardiovascular changes resulting in increased vasoconstriction and hypertension, and medications such as angiotensin...
-
Antioxidants in Chicken Egg Yolk: Effects of Cooking, Storage and Gastrointestinal Digestion
DownloadSpring 2015
Nimalaratne, Liyana Arachchilage Chamila K.
Eggs are one of the most nutritious and economically affordable foods. They contain high quality proteins and lipids and serve as an important source of vitamins and minerals. Despite the nutritional importance, the egg industry is vulnerable to the consumers’ perception about egg cholesterol and...
-
Are Sex and Estrogen Modulators of Sympathetic Vascular Control in Resting and Contracting Skeletal Muscle?
DownloadSpring 2018
The purpose of this thesis was to investigate whether sex and estrogen modulate sympathetic neurovascular control in resting and contracting skeletal muscle. This thesis also investigated the hypothesis that the effects of sex and estrogen on neurovascular control would be mediated by the signal...
-
Beneficial effects of simulated gastro-intestinal digests of fried egg and its fractions on blood pressure, plasma lipids and oxidative stress in spontaneously hypertensive rats
Download2014
Majumder, Kaustav, Jahandideh, Forough, Morton, Jude S., Davidge, Sandra T., Kaufman, Susan, Chakrabarti, Subhadeep, Panahi, Sareh, Wu, Jianping
Background We have previously characterized several antihypertensive peptides in simulated digests of cooked eggs and showed blood pressure lowering property of fried whole egg digest. However, the long-term effects of this hydrolysate and its fractions on blood pressure are not known. Therefore,...
-
Biochemical Characterization of ATP-Binding Cassette Transporter G1 Mediated Cholesterol Efflux
DownloadSpring 2012
ABCG1 mediates cholesterol efflux onto lipidated apolipoprotein A-I and plays an important role in macrophage reverse cholesterol transport, thereby preventing atherosclerosis. However, how ABCG1 mediates cholesterol efflux is unclear. We found that Cys514 located within the third putative...